突触后骨架蛋白与阿尔茨海默病

Postsynaptic scaffold proteins and Alzheimer disease

阿尔茨海默病(AD)是老年期最常见的慢性疾病之一,其患病率与年龄密切相关。突触作为神经元间信息传递的关键部位,与AD密切相关。突触结构与功能的丧失被认为是AD早期的标志。突触后密度蛋白-95、Shank和Homer蛋白是突触后主要骨架蛋白,在维持突触结构与功能中起重要作用,现就突触后骨架蛋白与AD的研究进展进行系统阐述。

Alzheimer disease(AD) is one of the most common chronic diseases in the elderly. The prevalence of AD is closely related to age. Synaptic structure, as a key part of information transmission between neurons, is closely related to AD. The loss of synaptic structure and function is considered to be a sign of early AD. Postsynaptic density protein-95, shank and Homer proteins are the main postsynaptic scaffold proteins, which play an important role in maintaining synaptic structure and function. We systematically describe the research progress of postsynaptic scaffold proteins and AD.