己糖胺途径与糖基化修饰关系的研究进展

Advances in the Research on Glycosylation in Hexosamine Biosynthesis Pathway

蛋白质糖基化(protein glycosylation)是一种广泛的翻译后修饰,包括合成不同的多糖核心,并将其添加到蛋白质一致序列内的特定氨基酸中。大多数糖蛋白从涉及内质网和高尔基体的分泌系统获得糖基,并分泌到与质膜相关的细胞壁或细胞外空间。糖基化修饰可以通过影响糖蛋白的折叠、分类、定位、丰度和活性来调节糖蛋白的功能。近年来多项研究报道葡萄糖代谢影响糖基化修饰。蛋白质糖基化修饰涉及多种代谢疾病和肿瘤的发生,己糖胺生物合成途径(hexosaminebiosynthesis pathway,HBP)与机体代谢和蛋白质糖基化修饰关系密切。

Protein glycosylation is a wide range of post-translational modifications,with the involvement of the synthesis of different polysaccharide cores and the attachment of which to particular amino acids within a protein consensus sequences.Most glycoproteins acquire glycosyl groups from the secretory system includes endoplasmic reticulum and Golgi apparatus,they are then secreted to the plasma membrane-associated cell wall or extracellular spaces.Glycosylation can regulate the function of glycoproteins by affecting their folding,sorting,localization,abundance and activity in cells.In recent years,many studies have reported that glucose metabolism have an effect on the protein glycosylation.This paper reviews the relationship between hexosamine biosynthesis pathway and the protein glycosylation.