NLR及PLR对儿童急性阑尾炎严重程度的预测价值

The predictive Value of NLR and PLR on the severity of acute appendicitis in children

目的 探讨中性粒细胞与淋巴细胞比例(NLR)及血小板与淋巴细胞比例(PLR)对儿童急性阑尾炎严重程度的价值预测。方法 选取住院并进行阑尾切除手术的82例急性阑尾炎患儿为研究对象,并根据术后病理分类分为非复杂性阑尾炎组26例和复杂性阑尾炎组56例。记录所述患儿的病程、性别、年龄、白细胞总数(WBC)、淋巴细胞数量、血小板数量、中性粒细胞数量、降钙素原(PCT)及超敏C反应蛋白(hs-CRP)指标,并计算NLR值和PLR值,利用受试者工作特征(ROC)曲线评价NLR及PLR,预测儿童阑尾炎病情严重程度的价值。结果 复杂性阑尾炎组中性粒细胞比例、RVR、hs-CRP、NLR、PLR均高于非复杂阑尾炎组,差异有统计学意义(P<0.05);复杂性阑尾炎组淋巴细胞比例低于非复杂性阑尾炎组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,急性阑尾炎患儿的NLR值与WBC、PCT及hs-CRP呈正相关性,PLR值与PCT呈正相关性。ROC曲线分析显示,NLR及PLR预测复杂性阑尾炎体现较高的特异性和敏感性。结论 NLR及PLR在儿童急性阑尾炎中可作为新的炎性指标,并对疾病严重程度有较好的预测价值。

Objective To investigate the value of neutrophil lymphocyte ratio(NLR) and platelet lymphocyte ratio(PLR) on the severity of acute appendicitis in children.Methods 82 children with acute appendicitis who were underwent appendectomy were selected as the research objects. According to postoperative pathology, they were divided into uncomplicated appendicitis group(26 cases) and complicated appendicitis group(56 cases). The course of disease, gender, age, white blood cell count, lymphocyte count, platelet count, neutrophil count, procalcitonin(PCT) and hypersensitive C-reactive protein(hs-CRP) of the children were collected, and the NLR and PLR were calculated. Receiver operating characteristic(ROC) curve was used to evaluate the value of NLR and PLR in predicting the severity of appendicitis in children.Results The percentage of neutrophils, PCT,hs-CRP,NLR and PLR in complicated appendicitis group were higher than those in non-complicated appendicitis group(P<0.05),and the Lymphocyte ratio in complicated appendicitis group was lower than that in non-complicated appendicitis group(P<0.05). Pearson correlation analysis showed that NLR was positively correlated with WBC,PCT and hs-CRP in children with acute appendicitis. PLR was positively correlated with PCT. ROC curve analysis showed that NLR and PLR had high specificity and sensitivity in predicting complicated appendicitis.Conclusion NLR and PLR can be used as new inflammatory indicators in children with acute appendicitis and have good predictive value for disease severity.