氟中毒对神经系统影响及作用机制的研究进展

Research progress on the effect of fluorosis on nervous system and its mechanism

氟中毒是由于长期接触过量氟引起的一种地方性疾病, 在许多国家被视为严重的公共卫生问题。近年来, 慢性氟中毒对中枢神经系统的损伤已引起国内外学者的广泛关注, 氟中毒引起神经毒性的机制包括氧化应激、炎症反应、自噬、神经递质及相关酶、神经信号通路改变、神经元能量代谢异常、细胞凋亡等方面, 可能造成人体大脑结构的永久性损伤、学习能力受损、记忆功能障碍和行为问题等。本文综述了氟中毒对神经系统的影响及相关机制, 为氟中毒的预防与治疗提供可靠依据。

Fluorosis is an endemic disease caused by prolonged exposure to excessive fluoride and is considered a serious public health problem in many countries.In recent years,the damage of chronic fluorosis to the central nervous system has attracted extensive attention from scholars at home and abroad.The mechanisms of neurotoxicity caused by fluorosis include oxidative stress,inflammatory reaction,autophagy,neurotransmitters and related enzymes,changes in neural signaling pathways,abnormal neuronal energy metabolism of neurons,cell apoptosis,etc.,causing permanent damage to human brain structure,impaired learning ability,memory dysfunction and behavioral problems.This article reviews the effects of fluorosis on the nervous system and related mechanisms,and provides a reliable basis for prevention and treatment of fluorosis.