人体重要寄生虫重组TPx参与免疫调控、免疫诊断及免疫预防的研究进展

Research progress of recombinant thioredoxin peroxidase of important human parasites involved in immunoregulation,immunodiagnosis and immunoprophylaxis

硫氧还蛋白过氧化物酶(TPx)属于过氧化物氧还蛋白超家族一员,广泛表达于寄生虫各个生长发育阶段及其排泄分泌物中。一方面,重组TPx蛋白可参与宿主免疫调控;另一方面,重组TPx蛋白作为诊断性抗原具有较高的敏感性和特异性,可用于寄生虫病的免疫诊断;此外,还可作为候选疫苗分子用于寄生虫病的免疫预防。文中就人体重要寄生虫重组TPx蛋白对宿主免疫调控、免疫诊断及免疫预防的研究进展做一综述。

Thioredoxin peroxidase(TPx)belongs to the superfamily of peroxiredoxins,which is widely expressed in various growth and development stages of parasites and their excretory secretions.On the one hand,recombinant TPx protein can participate in host immunoregulation;on the other hand,recombinant TPx protein has high sensitivity and specificity as a diagnostic antigen,and can be used for immunodiagnosis of parasitic diseases;in addition,it can also be used as a candidate vaccine molecule for the immunoprophylaxis of parasitic diseases.This paper reviews the research progress on host immunoregulation,immunodiagnosis and immunoprophylaxis by recombinant TPx protein of important human parasites.