慢性阻塞性肺疾病急性加重的量化评估与识别工具的研究进展

Advances in evaluating and identifying COPD exacerbations

慢性阻塞性肺疾病急性加重(AECOPD)是重要临床恶化事件,导致一系列不良结局。准确评估和识别AECOPD是进一步干预的前提,但AECOPD显著的异质性和对其潜在机制的有限认知,阻碍了精确定义的建立,增加了准确识别的难度。随着对AECOPD认识的深入,新近监测和评估技术相关研究的丰富,各种识别工具、方案和生物标志物不断涌现。本文汇总评估和识别AECOPD的研究进展,为AECOPD的准确识别提供参考,并为未来发展方向作出展望。

Acute exacerbations of chronic obstructive pulmonary disease(AECOPD)is an important clinical worsening event,resulting in a series of adverse outcomes.Accurate assessment and identification of AECOPD is a prerequisite for intervention,but the significant heterogeneity of AECOPD and limited understanding of its potential mechanism make it hard to establish a precisive definition and to form accurate identification.With the in-depth understanding of AECOPD and the enrichment of recent research on monitoring and assessment techniques,a variety of identification tools,schemes,and biomarkers continue to emerge.This paper summarizes the advances in the assessment and identification of AECOPD,so as to provide reference for accurate identification of AECOPD and to lead to the future development.