调控性非编码RNA在周围神经病理性疼痛中的作用研究进展

Research progress on the role of regulatory non-coding RNAs in peripheral neuropathic pain

调控性非编码RNA (ncRNA)主要包括长链非编码RNA (lncRNA)、微小RNA (miRNA)、环状RNA (circRNA)。近年来研究报道,ncRNA可通过调节离子通道、神经炎症和免疫平衡,参与轴突和髓鞘的损伤、修复与再生,调控神经元凋亡和自噬等多种途径,参与周围神经病理性疼痛的发生发展。因此,对调控性ncRNA在周围神经病理性疼痛中的作用靶点或生物标志物的研究进行总结十分重要。

Regulatory non-coding RNAs(ncRNAs) mainly include long non-coding RNAs(lncRNAs), microRNAs(miRNAs), and circular RNAs(circRNAs). In recent years, studies have reported that ncRNAs participate in the occurrence of peripheral neuropathic pain by regulating ion channels, neuro-inflammation and immune balance,mediating the damage, restoration and regeneration of axons and myelin sheaths, regulating neuronal apoptosis and autophagy, etc. Therefore, it is necessary to research and summarize the downstream targets and biomarkers of regulatory ncRNAs involved in peripheral neuropathic pain.