白内障发病机制与防治策略的研究进展

Advances in pathogenesis and pharmacotherapy of cataract

白内障是全球首位致盲性眼病.随着人口老龄化加剧,白内障将导致巨大的社会和经济负担.目前,手术治疗作为唯一的治愈手段,仍存在个体疗效差异、手术禁忌症、并发症及经济负担等诸多局限性,已不能满足当前社会需求.因此,研究白内障发病机制,找寻白内障潜在的治疗药物一直是研究的热点.本文基于团队目前的工作内容,从白内障发病机制、白内障模型进展及白内障防治药物的开发筛选等方面对白内障的发病机制及防治策略进行综述.

Cataract is the leading cause of vision impairment worldwide.As the population ages,the prevalence of cataract will increase rapidly,which has caused a substantial social and economic burden.Although cataract surgery is effective,it still suffers from complications and high costs and could not meet the increasing surgery demand.Therefore,pharmacological treatment for cataracts is cheaper and more readily available for patients.Therefore,research on the pathogenesis of cataract and exploring potential therapeutic drugs for cataract have always been a research hotspot for years.Based on our team’s current work,this article summarizes the pathogenesis and pharmacotherapy strategies of cataract from the pathogenesis of cataract,the cataract disease models,and the development of anti-cataract drugs.