摘要
目的:研究藏药材柳兰(Epilobium angustifolium)中黄酮类化学成分。方法:采用正、反相硅胶、MCI大孔树脂、Sephadex LH-20凝胶柱色谱及中低压柱色谱、制备型高效液相色谱分离纯化化合物,利用核磁共振和质谱等方法确定化合物结构。结果:从植物柳兰全草乙醇提取物的乙酸乙酯萃取部位中分离得到11个化合物,分别鉴定为槲皮素-3-O-β-D-葡萄糖醛酸苷(1)、金丝桃苷(2)、槲皮苷(3)、木犀草素(4)、槲皮素(5)、阿福豆苷(6)、山奈酚-3-O-α-L-阿拉伯呋喃糖苷(7)、槲皮素-3-O-α-L-阿拉伯呋喃糖苷(8)、桑色素-3-O-α-L-鼠李糖苷(9)、槲皮素-3-O-α-D-阿拉伯吡喃糖苷(10)和芦丁(11)。结论:从藏药材柳兰乙醇提取物的乙酸乙酯萃取部位中分离得到11种黄酮类成分。其中,化合物1为首次从柳兰中分离得到,化合物7、9、10为首次从柳叶菜科植物中分离得到。
Objective To investigate the chemical constituents of flavonoids from Zang medicine Epilobium angustifolium L..Methods The silica gel, reversed phase C-18 silica gel, MCI-gel, Sephadex LH-20 column chromatographic technique and preparative high performance liquid chromatography were applied to isolate and purify the chemical constituents from Epilobium angustifolium L..The structures of the isolated compounds were identified by means of MS and NMR spectroscopy.Results 11 compounds were isolated from the ethanol extracts of Epilobium angustifolium L., which were identified as quercetin 3-O-β-D-glucuronide(1),hyperoside(2),quercitrin(3),luteolin(4),quercetin(5),afzelin(6),kaempferol-3-α-L-arabinofuranoside(7),quercetin-3-α-L-arabinofuranoside(8),morin-3-O-α-L-rhamnoside(9),quercetin-3-O-α-D-arabinopyranoside(10),and rutin(11).Conclusion Compounds 1 was isolated from this plant for the first time.Compounds 7,9 and 10 were isolated from Onagraceae for the first time.
作者
张金魁
林鹏程
王志波
刘晓翠
王敏
马敏
ZHANG Jinkui;LIN Pengcheng;WANG Zhibo;LIU Xiaocui;WANG Min;MA Min(College of Pharmacy,Qinghai Minzu University,Xining 810007,China;College of Management and Economics,Tianjin University,Tianjin 300072,China;Key Laboratory of Plant resources of Qinghai-Tibet Plateau in Chemical Research,Xining 810007,China)
出处
《中国民族民间医药》
2022年第23期41-45,共5页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
青海省自然科学基金(藏药材柳兰抗肿瘤靶标分子的化学成分及质量控制技术研究)(2019-ZJ-905)。
关键词
藏药材
柳兰
黄酮类成分
Tibet Medicine
Epilobium angustifolium L.
Flavonone