经导管主动脉瓣置换术后血小板变化特点及抗栓策略的研究进展

Development of platelet change characteristics and antithrombotic strategies after transcatheter aortic valve replacement

经导管主动脉瓣置换术(Transcatheter aortic valve implantation,TAVI)是一种新兴的,以微创方式安全有效治疗主动脉瓣病变的手术方式,随着研究的深入与手术技术的提升,其适应人群也在逐渐扩大,但TAVI术后血小板变化特点及围术期最佳抗栓方式并无定论。我们回顾TAVI后血小板变化特点及相关因素、围术期不同抗栓治疗的相关临床研究结果,以探讨TAVI后个体化抗栓策略。

Transcatheter aortic valve implantation(TAVI)is an emerging,minimally invasive surgical procedure for the safe and effective treatment of aortic valve lesions,and with the advancement of medical research and surgical techniques,the population for TAVI is gradually expanding,but,the characteristics of platelet changes after TAVI and the best antithrombotic strategy in the perioperative period are not conclusive.We review the characteristics of platelet changes and related factors after TAVI,and the outcomes of clinical studies related to different antithrombotic treatments in the perioperative period,in order to discuss the individualized antithrombotic strategy after TAVI.