失眠障碍脑功能静息态功能磁共振成像研究进展

Research progress of resting-state functional magnetic resonance imaging in the brain function of insomnia disorder

失眠障碍(insomnia disorder,ID)是最常见的睡眠障碍,持续失眠与高血压甚至与癌症相关。阐明ID的神经机制对ID的治疗前评估、治疗策略制订和患者管理意义重大。静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)因其可以反映脑组织血氧水平而间接反映脑功能代谢成为研究ID神经机制的有力手段。基于rs-fMRI的各种分析方法在近年来得到不断发展,笔者从局部脑活动分析的区域研究方法和功能连接分析的整合研究方法两方面展开,就rs-fMRI在ID脑功能方面应用研究的最新进展进行综述,讨论了当前研究的不足,并展望了未来研究方向,旨在为进一步探索ID更深层次的神经机制研究提供更坚实可靠的理论基础和研究证据。

Insomnia disorder(ID)is the most common sleep disorder,and persistent insomnia is associated with hypertension and even cancer.Resting-state functional magnetic resonance imaging(rs-fMRI)can reflect the blood oxygen level of brain tissue,and indirectly reflect brain function metabolism,which has become a powerful means to study insomnia,and is of great significance for pre-treatment evaluation,treatment strategy and disease management of insomnia.Various analysis methods based on rs-fMRI have been developed in recent years.In this review,we summarize the research progress of rs-fMRI brain function in insomnia disorder,discuss the common problems troubling current studies and shed light upon the outlook on the development trends,as well as important research directions.This review aims to provide a rationale for further exploration of neural mechanisms in ID.