酰胺质子转移加权成像在女性生殖系统的研究进展

Advanced application of amide proton transfer imaging in female reproductive system

酰胺质子转移加权(amide proton transfer-weighted, APTw)成像是化学交换饱和转移(chemical exchange saturation transfer, CEST)成像中的一种,其基于蛋白质和多肽链上的酰胺质子与游离水之间的质子交换来间接反映组织中的pH值和蛋白质浓度。APTw成像作为一种无创的磁共振分子成像新技术,可以早期监测蛋白质浓度变化反映细胞异常增殖,以更早发现肿瘤,能够在子宫体、宫颈、卵巢病变中提供重要的影像学信息,为临床的诊断、危险分层及预后方面提供帮助,为临床治疗提供重要参考。本文主要阐述APTw成像在女性生殖系统的研究进展、发展前景及尚需解决的问题。

Amide proton transfer-weighted(APTw) imaging is a method in chemical exchange saturation transfer imaging, which indirectly indicates pH and protein concentration in the tissue based on the proton exchange between amide protons on proteins and polypeptide chains and water protons. APTw imaging, as a new non-invasive magnetic resonance molecular imaging technology, can monitor the changes of protein concentration in early stage to reflect the abnormal proliferation of cells, so as to detect tumors earlier, and can provide important imaging information in uterine body, cervix, and ovarian lesions. It provides help in diagnosis, risk stratification and prognosis, and provides an important reference for clinical treatment. This paper mainly describes the research progress,development prospect and problems to be solved of APTw imaging in female reproductive system.