基于CiteSpace对青藤碱在中医药研究应用现状的可视化分析

CiteSpace-based visualization of the current status of the application of Sinomenine in Chinese medicine research

目的利用CiteSpace分析国内外近20年青藤碱中医药相关研究的现状及未来发展趋势。方法检索中国知网和Web of Science数据库收录的2001年1月至2022年4月青藤碱相关研究文献,运用Cite Space软件对作者、国家、机构、关键词进行可视化分析。结果共得到中文文献973篇、英文文献264篇。近20年青藤碱研究的发文量呈波动上升趋势。周莉玲和刘良分别是中英文发文量最高的作者,发文机构集中在国内,以广州中医药大学为主,但团队及机构间欠缺合作。关键词分析显示,青藤碱、增殖、细胞凋亡、大鼠、青风藤是青藤碱的中文研究热点,细胞表达、凋亡、活化、代谢、抑制、类风湿关节炎、小鼠、增殖是英文研究热点,国内外研究趋势侧重细胞凋亡与细胞增殖。结论当前青藤碱领域处于发展上升阶段,研究热点和趋势是细胞凋亡与细胞增殖,但团队机构间合作少,应加大交流合作,有利于推动青藤碱的长足发展。

Objective To analyze the current status and future development trend of Chinese medicine related research on Sinomenine in the past 20 years at home and abroad by scientific knowledge mapping methods.Methods The research literatures related to Sinomenine from January 2001 to April 2022 included in China Knowledge Network and Web of Science databases were searched,and the authors,countries,institutions,and keywords were visualized analyzed by Cite Space software.Results A total of 973 Chinese literatures and 264 English literatures were obtained.The number of publications on Sinomenine research had shown a fluctuating upward trend in the last 20 years.Zhou Liling and Liu Liang were the authors with the highest number of publications in English and Chinese,respectively.The publishing institutions were concentrated in China,mainly in Guangzhou University of Chinese Medicine,but there was a lack of cooperation between teams and institutions.Keywords analysis showed that Sinomenine,proliferation,apoptosis,rat,and cyanophylline were the hotspots of cyanophylline research in Chinese,cell expression,apoptosis,activation,metabolism,inhibition,rheumatoid arthritis,mouse,and proliferation were the hotspots of research in English,and domestic and foreign research trends focused on apoptosis and cell proliferation.Conclusion At present,the field of Cyanophylline is in the rising stage of development,and the research hotspots and trends are apoptosis and cell proliferation,but there is little cooperation among team institutions,and the communication and cooperation should be increased,which is conducive to promoting the long-term development of cyanophylline.