miR-21和miR-29与肾纤维化的研究进展

Research progress on the expression of miR-21 and miR-29 and renal fibrosis

肾纤维化是肾脏疾病进展到后期的主要病理变化,炎症刺激为肾纤维化进展的主要因素,其不可逆性及转归差异已成为现代医学的难题之一。微RNA(miRNA)是一种短链内源性非编码小分子RNA,以稳定形式存在于血浆、血清及体液中,转录后调控编码蛋白基因,参与多种生物学过程的调控。研究表明,miRNA中包含的部分miRNA在纤维化过程中发挥重要作用,是纤维化/炎症过程的关键调节因子。在肾脏疾病中,miR-21、miR-29调控靶基因及相关信号通路,作用于炎症/促纤维化进程。本文将重点关注炎症细胞浸润的肾纤维化发病机制的信号通路,从分子层面探讨miR-21、miR-29在肾纤维化中的机制及潜在治疗作用。

Renal fibrosis is the main pathological change of kidney disease progression to the later stage,and inflammatory stimulation is the main factor of renal fibrosis progression.Its irreversibility and outcome difference have become one of the difficult problems in modern medicine.The micro RNA(miRNA)is a short-chain endogenous non-coding small molecule RNA present in stable form in plasma,serum and body fluids,post-transcriptionally regulated encoding protein genes,involved in the regulation of various biological processes.Studies have shown that some of the miR contained in miRNA play an important role in the fibrosis process and are key regulatory factors in the fibrosis/inflammation process.In kidney disease,miR-21 and miR-29 regulate target genes and related signaling pathways,acting on inflammation/promoting fibrosis process.This paper will focus on the signaling pathway of the pathogenesis of renal fibrosis infiltrated by inflammatory cells,and explore the mechanism and potential therapeutic effects of miR-21 and miR-29 in renal fibrosis from the molecular level.