《备急千金要方》和《千金翼方》治疗肾系水肿用药规律挖掘研究

Study on drug laws of Beiji Qianjin Yao Fang and Qianjin Yi Fang in the treatment of renal edema based on data mining

目的运用数据挖掘技术,挖掘并总结《备急千金要方》和《千金翼方》(以下简称《千金方》)中治疗肾系水肿的用药规律。方法选取《千金方》中治疗肾系水肿的处方,建立标准的医案数据库,运用古今医案云平台统计用药频次、药性、药味、归经及药物关联规则和聚类分析。结果本研究共纳入《千金方》治疗肾系水肿条文67条,涉及方剂67首,其中《备急千金要方》44首,《千金翼方》23首;涉及中药144味,使用频次较高的药物前3位为白术、茯苓、桂枝;药性多温,药味多甘、辛、苦,多归肺、脾、肾经;药效以利水消肿、健脾、利水渗湿、祛风止痛、燥湿利水等居多。两味药模式的关联规则中以防己→白术置信度最高;使用频率大于20次的药物经过聚类分析可聚为4类。结论通过数据挖掘展示出了《千金方》中肾系水肿的辨治思路,即形成了以虚实为纲,以三焦为辨,以分消为法的思路,为中药治疗肾系水肿的临床实践提供参考。

Objective To use the data mining technology to explore and summarize the drug laws of the treatment of renal edema in Beiji Qianjin Yao Fang and Qianjin Yi Fang(hereinafter referred to as Qianjin Fang).Methods The prescriptions for treating renal edema in Qianjin Fang were selected to establish a standard medical record database,and the cloud platform of ancient and modern medical records was used to make statistics on drug frequency,drug properties,drug flavor,channel tropism,drug association rules,and cluster analysis.Results A total of 67 formulas for the treatment of renal edema from Qian Jin Fang were included in this study,involving 67 prescriptions,among which 44 were Beiji Qianjin Yao Fang and 23 were Qianjin Yi Fang.A total of 144 traditional Chinese medicine were involved,and the top three drugs with high frequency were Atractylodis Macrocephalae Rhizoma,Poria,and Cinnamomi Ramulus.The drug properties were more warm,the drug flavors were more sweet,pungent,and bitter,more return to the lung,spleen,kidney channel.The drug efficacy was more inducing diuresis for removing edema,invigorating spleen,diuresis and diffusing dampness,dispelling pathogenic wind and relieving pain,eliminating dampness and diuresis,and so on.In the association rules of the two drug patterns,the confidence of Stephaniae Tetrandrae Radix→Atractylodis Macrocephalae Rhizoma was the highest.Drugs used more than 20 times could be grouped into four groups by cluster analysis.Conclusion Through data mining,the differentiation and treatment ideas of renal edema in Qianjin Fang are shown,that is,the idea of taking deficiency and excess as the key line,sanjiao as the differentiation method and elimination as the method is formed,which provided reference for the clinical practice of traditional Chinese medicine treatment of renal edema.