中青年体检人群脂联素水平与代谢综合征的相关性研究

Relationship between adiponectin level and metabolic syndrome in young and middle-aged physical examination population

目的 探讨中青年体检人群脂联素水平与代谢综合征的相关性。方法 以体检中青年人群为研究对象,按脂联素水平三分位数将研究人群分为3组,分析脂联素水平与代谢综合征的相关性。结果 脂联素与体重指数(BMI)(r=-0.283,P<0.001)、WC(r=-0.347,P<0.001)、收缩压(SBP)(r=-0.225,P<0.001)、舒张压(DBP)(r=-0.253,P<0.001)、三酰甘油(TG)(r=-0.257,P<0.001)、空腹血糖(FPG)(r=-0.146,P=0.023)、2 hPG(r=-0.184,P=0.004)和胰岛素抗抗指数(Homa-IR)(r=-0.312,P<0.001)呈负相关,与高密度酯蛋白胆固醇(HDL-C)呈正相关(r=0.445,P<0.01)。研究人群代谢综合征检出率为34.0%。中三分位数组高三酰甘油血症检出率高于上三分位数组,下三分位数组腹型肥胖、高血糖、高三酰甘油血症和低高密度脂蛋白血症检出率高于上三分位数组(P<0.05)。多因素Logistic回归分析显示,校正年龄、性别、吸烟史、饮酒史和BMI后,中三分位数组和下三分位数组发生代谢综合征的危险是上三分位数组的3.296(95%CI:1.041~10.434,P=0.042)倍和17.778(95%CI:5.372~58.836,P<0.001)倍。结论 脂联素水平与中青年体检人群代谢综合征显著相关,低脂联素水平是代谢综合征的独立危险因素。

Objective To investigate the relationship between adiponectin level and metabolic syndrome in young and middle-aged physical examination population.Methods The young and middle-aged subjects for physical examination as the research object, the study subjects was allocated into three groups according to the tertile of adiponectin level, and the correlation between the level of adiponectin and metabolic syndrome was analyzed.Results Adiponectin negatively correlated with body mass index(BMI)(r=-0.283, P<0.001), WC(r=-0.347, P<0.001), systolic blood pressure(SBP)(r=-0.225, P<0.001), diastolic blood pressure(DBP)(r=-0.253, P<0.001), triacylglycerol(TG)(r=-0.257, P<0.001), fasting plasma glucose(FPG)(r=-0.146, P=0.023), 2-hour postprandial glucose(2-hPG)(r=-0.184, P=0.004) and homeostasis model assessment of insulin resistance(HOMA-IR)(r=-0.312, P<0.001). Adiponectin positively correlated with high density lipoprotein cholesterol(HDL-C)(r=0.445, P<0.01). The metabolic syndrome rate was 34.0%. The hypertriglyceridemia rate was higher in the middle tertile group vs the high tertile group, the rates of abdominal obesity, hyperglycemia, hypertriglyceremia and low-density lipoproteinemia were higher in the lower tertile group vs the high tertile group(P<0.05). Multivariate logistic regression analysis showed that adjusting for age, sex, smoking history, drinking history, and BMI, the risk of metabolic syndrome in the middle and low tertile group was 3.296(95% CI: 1.041~10.434, P=0.042) times and 17.778(95% CI: 5.372~58.836, P<0.001) times more than the upper tertile, respectively.Conclusion For young and middle-aged physical examination subjects, adiponectin level is closely correlated with metabolic syndrome;low level of adiponectin is an independent risk factor for metabolic syndrome.