参芪温阳阴道膨胀栓与盆底生物反馈电刺激治疗女性压力性尿失禁的有效性与安全性比较

Comparison of efficacy and safety of Shenqi Wenyang Vaginal swelling Supposit and pelvic floor biofeedback electrical stimulation in the treatment of female stress urinary incontinence

目的评价参芪温阳阴道膨胀栓与盆底生物反馈电刺激治疗女性压力性尿失禁的有效性与安全性。方法选取240例轻中度女性压力性尿失禁患者,按照随机数字表法分为试验组和对照组,每组120例。试验组接受参芪温阳阴道膨胀栓治疗,对照组接受盆底生物反馈电刺激治疗。比较两组治疗效果、24h尿失禁发作频率、盆地肌电评分、尿失禁问卷表简表(ICI-Q-SF)评分、依从性、不良反应,以及随访至12个月的复发情况。结果试验组治疗总有效率为81.67%,高于对照组的59.17%,差异有统计学意义(P<0.05)。治疗后随访至12个月,试验组复发率显著低于对照组,差异有统计学意义(P<0.05)。治疗后4、8周,两组平均24h尿失禁发作频率少于本组治疗前,且试验组平均24h尿失禁发作频率少于对照组,差异有统计学意义(P<0.05)。治疗后4、8周,两组盆底肌电评分高于本组治疗前,且试验组盆底肌电评分高于对照组,差异有统计学意义(P<0.05)。治疗后4、8周,两组ICI-Q-SF评分均低于本组治疗前,且试验组ICI-Q-SF评分低于对照组,差异有统计学意义(P<0.05)。试验组患者依从性高于对照组,差异有统计学意义(P<0.05)。试验组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论参芪温阳阴道膨胀栓治疗女性压力性尿失禁效果、盆底肌电改善程度、依从率优于盆底生物反馈电刺激治疗,不良反应发生率及复发率低于盆底生物反馈电刺激治疗。

Objective To evaluate the efficacy and safety of Shenqi Wenyang vaginal swelling Supposition and pelvic floor biofeedback electrical stimulation in the treatment of female stress urinary incontinence. Methods 240 female patients with mild to moderate stress urinary incontinence were divided into experimental group and control group according to random number table method, 120 cases in each group. The experimental group received Shenqi Wenyang vaginal dilatation supposit and the control group received pelvic floor biofeedback electrical stimulation. Treatment effect, 24 h frequency of urinary incontinence, basin electromyography score, ICI Q-SF score of urinary incontinence questionnaire, compliance, adverse reactions, and recurrence at 12 months of follow-up were compared between the two groups. Results The total effective rate of the experimental group was 81.67%, which was higher than 59.17% of the control group, and the difference was statistically significant(P<0.05). Followup to 12 months after treatment, the recurrence rate of experimental group was significantly lower than that of control group, the difference was statistically significant(P<0.05). At 4 and 8 weeks after treatment, the average 24 h urinary incontinence attack frequency of the two groups was lower than before treatment, and the average 24 h urinary incontinence attack frequency of the experimental group was lower than that of the control group, the difference was statistically significant(P<0.05). At 4 and 8 weeks after treatment, the pelvic floor electromyography score of the two groups was higher than that before treatment, and the test group was higher than the control group, the difference was statistically significant(P<0.05). At 4 and 8 weeks after treatment, ICI Q-SF scores in 2 groups were lower than before treatment, and ICI Q-SF scores in experimental group were lower than control group,with statistical significance(P<0.05). The compliance of experimental group was higher than that of control group, the difference was statistically significant(P<0.05). The incidence of adverse reactions in experimental group was lower than that in control group, and the difference was statistically significant(P<0.05). Conclusion Shenqi Wenyang Vaginal dilatation supposit in the treatment of female stress urinary incontinence is better than that in the treatment of pelvic floor electromyoelectric improvement and compliance rate, and the incidence of adverse reactions and recurrence rate is lower than that in the treatment of pelvic floor electrostimulation.