未用药抑郁障碍患者血清25(OH)D水平分布特征

Distribution characteristics of serum 25-hydroxyvitamin D levels in patients with first-episode drug-naive depressive disorders

目的探讨不同性别、年龄的未用药抑郁障碍患者血清25-羟维生素D[25(OH)D]水平分布情况,并与其他精神疾病患者进行比较以指导临床工作。方法纳入1583例未用药的精神疾病患者,记录其性别、年龄、诊断和血清25(OH)D水平,比较抑郁障碍与其他精神障碍疾病、抑郁障碍中不同性别和年龄段患者的血清25(OH)D水平。结果抑郁障碍患者血清25(OH)D水平低于精神分裂症、焦虑障碍和睡眠障碍患者(P均<0.05)。抑郁障碍患者中血清25(OH)D水平缺乏者占55.7%、不足者占37.0%、充足者占7.4%。女性患者的血清25(OH)D水平低于男性患者(P<0.001)。未成年患者的血清25(OH)D水平低于老年患者(P<0.001)。结论抑郁障碍患者的血清25(OH)D水平与其他精神疾病患者之间存在差异,提示可进一步探讨血清25(OH)D在抑郁障碍患者起病、转归过程中的作用。抑郁障碍患者中血清25(OH)D缺乏和不足普遍,尤其是女性及未成年患者,提示需要对这部分重点人群进行血清25(OH)D水平的检测,及时补充维生素D。

Objective To retrospectively analyze the serum levels of 25-hydroxyvitamin D[25(OH)D]in patients with drug-naive depression and its correlation with gender and age,compare with their counterparts with other mental disorders to guide clinical work.Methods A total of 1583 drug-naive patients with mental illness were enrolled.The gender,age,diagnosis,and serum 25(OH)D value of all patients were recorded.Serum 25(OH)D levels were compared between depression patients and those with other mental disorders,and compared among depression patients of different genders and ages.Results Serum 25(OH)D level in patients with depressive disorders was higher than that in those with bipolar disorders,whereas lower than those in their counterparts with organic mental disorders,schizophrenia,anxiety disorders,and sleep disorders(all P<0.05).Serum 25(OH)D level was deficient in 55.7%,insufficient in 37.0%and sufficient in 7.4%of patients with depressive disorders.Serum 25(OH)D level in female patients was lower than that in male counterparts(P<0.001).Serum 25(OH)D level in juvenile patients was lower than that in elderly counterparts(P<0.001).Conclusions Serum 25(OH)D level in patients with depressive disorder differs from those in their counterparts with other mental disorders,prompting that the role of serum 25(OH)D in the episode and prognosis of depressive disorders deserves further investigation.Serum 25(OH)D deficiency and insufficiency are common in patients with depressive disorders,especially in female and juvenile patients.These findings suggest that it is necessary to deliver screening of serum 25(OH)D level in these populations and supplement vitamin D in a timely manner.