聚乳酸-羟基乙酸共聚物纳米粒载中药抗肿瘤成分的研究进展

Research progress on antitumor components in traditional Chinese medicine loaded with PLGA nanoparticles

聚乳酸-羟基乙酸共聚物(polylactic-co-glycolic acid,PLGA)是由乳酸和羟基乙酸单体按所需比例聚合而成的有机材料,具有可生物降解性和良好的生物相容性、结构可修饰性、释药速度可控等优点,被广泛用于药物递送领域。随着对活性物质研究的深入,中药抗肿瘤成分被证实具有高效、低毒的优势,成为肿瘤治疗领域的研究热点。近年来,通过乳化溶剂挥发法、复乳法、沉淀法、透析法成功将中药抗肿瘤成分负载在PLGA纳米粒中,应用于改善药物的性质、靶向递药系统、免疫佐剂等领域。综述PLGA纳米粒载中药抗肿瘤成分的制备和应用进展,以期为中药抗肿瘤成分的新型递药系统研究提供参考。

Polylactic co-glycolic acid(PLGA),an organic polymer material,is composed of lactic acid and glycolicacid in the required proportion.It has the advantages of biodegradability,good biocompatibility,structural modification and controllable drug release speed,which has been widely used in the field of drug delivery.With the in-depth study of the active substances,the antitumor components in traditional Chinese medicine have been proven to have the advantages of high efficiency and low toxicity,which has become a research hotspot in the field of tumor therapy.In recent years,the antitumor components in traditional Chinese medicine have been successfully loaded into PLGA nanoparticles through emulsion-solvent evaporation method,double emusion method,nanoprecipitation method and dialysis method,which have been applied to improve the properties of drug,targeting system,immune adjuvant and other fields.The preparation and application of PLGA nanoparticles loaded antitumor components in traditional Chinese medicine in recent years are reviewed in this paper,hoping to provide references for the research of new drug delivery system of antitumor components of traditional Chinese medicine.