高内脏脂肪指数与高尿酸血症的相关性分析

Correlation analysis of high visceral adiposity index and hyperuricemia

目的 探讨连云港市高血压人群内脏脂肪指数(visceral adiposity index, VAI)水平与新发高尿酸血症(hyperuricemia, HUA)的相关性,为HUA的早期预防以及疾病控制提供参考和依据。方法 本研究来自中国脑卒中一级预防试验的尿酸子研究,共10 513名尿酸正常[尿酸<357μmol/L (6 mg/dL)]的高血压患者纳入分析。本研究主要终点为新发HUA,定义为末次随访男性血尿酸浓度≥417μmol/L(7 mg/dL)或女性血尿酸浓度≥357μmol/L(6 mg/dL)。结果 本研究共纳入了10 513例尿酸正常的高血压受试者。平均随访4.4年之后,共有1 642(15.6%)例受试者发生了HUA。分析结果显示,与VAI<2.98(第一至三分位)的受试者相比,VAI≥2.98(第四分位)的受试者新发HUA的发生风险升高(13.8%vs. 21.1%;OR:1.17;95%CI:1.01~1.36;P<0.001)。此外,分层分析显示这种风险关系独立于组成VAI的四个指标(交互作用均有P>0.05)。结论 在连云港市的高血压人群中,VAI越大的人群患上HUA的风险越高。

Objective The relation between visceral adiposity index(VAI) and new-onset hyperuricemia remains largely understudied. This study seeks to further investigate the association between VAI and the risk of hyperuricemia by examining possible effect modifies in hypertensive patients. Methods A total of 10 513 hypertensive patients with normal uric acid(UA) concentrations [<357 μmol/L(6 mg/dL)] who participated the UA Sub-study of the China Stroke Primary Prevention Trial(CSPPT) were enrolled. Our primary outcome was new-onset hyperuricemia, which was defined as a UA concentration ≥417 μmol/L(7 mg/dL) in men or ≥357 μmol/L(6 mg/dL) in women at the exit visit. Results Over a median follow-up of 4.4 years, 1 642(15.6%) participants developed new-onset hyperuricemia. When VAI was assessed as quartiles, a significantly higher risk of new-onset hyperuricemia was found in participants in quartile 4(≥2.98;OR:1.17;95% CI: 1.01-1.36) compared with those in quartile 1-3(<2.98). Furthermore, the positive relation was independent of abnormal VAI components or numbers of abnormal VAI components(all Pinteractions>0.05). Conclusions There is a positive relationship between baseline VAI and the risk of new-onset hyperuricemia in a sample of Chinese hypertensive individuals.