血清IL-6联合ABCD3-I评分对孤立性眩晕患者并发脑梗死的诊断价值

Diagnostic value of serum IL-6 combined with ABCD3-I score in patients with isolated vertigo complicated with cerebral infarction

目的 探讨血清白细胞介素-6(IL-6)联合ABCD3-I评分对孤立性眩晕患者并发脑梗死的诊断价值。方法 回顾性选取2020年3月至2021年3月临汾市中心医院收治的孤立性眩晕患者87例,依据并发脑梗死情况分为并发组(n=20)、未并发组(n=67)两组。统计分析两组患者的基线资料、血清IL-6水平、ABCD3-I评分;多因素Logistic回归分析孤立性眩晕患者并发脑梗死的危险因素;并统计分析孤立性眩晕患者并发脑梗死诊断中的血清IL-6水平、ABCD3-I评分单独与联合测定的价值。结果 87例患者中,并发脑梗死20例,脑梗死发病率为22.99%。并发组患者的高血压、糖尿病、短暂性脑缺血发作、冠状动脉粥样硬化性心脏病、吸烟史、椎基底动脉狭窄/发育不良、脑灌注下降比率、总胆固醇、空腹血糖水平均明显高于未并发组,差异均有统计学意义(P<0.05)。并发组患者的血清IL-6水平明显高于未并发组,ABCD3-I评分明显高于未并发组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,孤立性眩晕患者并发脑梗死的危险因素包括合并高血压、糖尿病、基底动脉狭窄/发育不良、高血清IL-6水平、高ABCD3-I评分(P<0.05)。孤立性眩晕患者并发脑梗死血清IL-6水平、ABCD3-I评分联合诊断孤立性眩晕并发脑梗死的敏感度、特异度均高于IL-6水平、ABCD3-I评分单独检测(P<0.05)。结论 孤立性眩晕患者并发脑梗死患者的血清IL-6水平和ABCD3-I评分明显高于未并发脑梗死的患者,血清IL-6、ABCD3-I评分联合诊断孤立性眩晕并发脑梗死较单独血清IL-6水平、ABCD3-I评分检测诊断效能高。

Objective To investigate the value of combined diagnosis of serum interleukin-6(IL-6) and ABCD3-I in patients with isolated vertigo complicated with cerebral infarction. Methods 87 patients with isolated vertigo in Linfen Central Hospital from March 2020 to March 2021 were retrospectively selected and divided into two groups according to the complication of cerebral infarction: concurrent group(n=20) and non-concurrent group(n=67). The baseline data, serum IL-6 level and ABCD3-I score of the two groups were statistically analyzed. The risk factors of patients with isolated vertigo complicated with cerebral infarction were analyzed by multivariate Logistic regression, and the value of serum IL-6 level and ABCD3-I score in the diagnosis of patients with isolated vertigo complicated with cerebral infarction was statistically analyzed.Results Among 87 patients, 20 cases were complicated with cerebral infarction, the incidence of cerebral infarction was 22.99%. Hypertension, diabetes mellitus, TRANSIENT ischemic attack, coronary atherosclerotic heart disease, smoking history, vertebrobasilar artery stenosis/dysplasia, decreased cerebral perfusion ratio, TC and FPG levels in concurrent group were higher than those in non-concurrent group, the differences were statistically significant(P<0.05). The serum IL-6 level in concurrent group was higher than that in non-concurrent group, and ABCD3-I score was higher than that in non-concurrent group, the differences were statistically significant(P<0.05). Multivariate Logistic regression analysis showed that the risk factors for cerebral infarction in isolated vertigo patients included hypertension, diabetes, basilar artery stenosis/dysplasia, high serum IL-6 level, and high ABCD3-I score(P<0.05). The sensitivity and specificity of combined diagnosis of Isolated vertigo complicated with cerebral infarction of serum IL-6 level and ABCD3-I score in patients with isolated vertigo complicated with cerebral infarction were higher than those of single diagnosis(P<0.05). Conclusion The serum IL-6 level and ABCD3-I score of patients with isolated vertigo complicated with cerebral infarction were significantly higher than those of patients without cerebral infarction. ABCD3-I score detection has high diagnostic efficiency.