血府逐瘀汤对急性轻中度颅脑损伤患者机体蛋白质代谢和神经内分泌调节的影响

The Influence of Blood Mansion Stasis-Expelling Decoction on Protein Metabolism and Neuroendocrine Regulation in Patients with Acute Mild to Moderate Craniocerebral Injury

目的:观察血府逐瘀汤对急性轻中度颅脑损伤患者机体蛋白质代谢和神经内分泌调节的影响。方法:选取2020年7月至2021年12月江西省宜春市万载县中医院收治的急性中轻度颅脑损伤患者72例,按照随机数字表法分为对照组和观察组,每组36例。对照组给予西医对症治疗,观察组在对照组的基础上给予血府逐瘀汤治疗。观察两组患者治疗前后Barthel指数、汉密尔顿抑郁量表(hamilton depression scale, HAMD)评分、汉密尔顿焦虑量表(hamilton anxiety scale, HAMA)评分、功能综合评分量表(functional comprehensive assessment, FCA)评分及患者机体蛋白代谢和神经内分泌调节情况。结果:两组治疗后2周Barthel指数、FCA评分高于治疗前,观察组治疗后2周Barthel指数和FCA评分高于对照组,差异具有统计学意义(P<0.05);两组治疗后2周HAMD评分、HAMA评分低于治疗前,观察组治疗后2周HAMD评分、HAMA评分低于对照组,差异具有统计学意义(P<0.05);两组治疗后2周促肾上腺皮质激素(adreno cortico tropic hormone, ACTH)、促甲状腺激素(thyroid stimulating hormone, TSH)、催乳素(prolactin, PRL)水平低于治疗前,观察组治疗后2周ACTH、TSH和PRL水平低于对照组,差异具有统计学意义(P<0.05);两组治疗后2周血清前白蛋白、白蛋白和转铁蛋白水平高于治疗前,观察组治疗后2周血清前白蛋白、白蛋白和转铁蛋白水平高于对照组,差异具有统计学意义(P<0.05)。结论:血府逐瘀汤联合西医常规治疗急性轻中度颅脑损伤,能够促进患者日常生活能力的恢复,还可提高患者功能综合能力,改善机体蛋白质代谢和神经内分泌调节。

Objective: To observe the influence of Blood Mansion Stasis-Expelling Decoction on protein metabolism and neuroendocrine regulation in patients with acute mild to moderate craniocerebral injury.Methods: A total of 72 patients with acute moderate to mild craniocerebral injury admitted to Wanzai County Hospital of Traditional Chinese Medicine in Yichun City, Jiangxi Province from July 2020 to December 2021were selected and divided into the conventional group and the observation group according to random number table, with 36 cases in each group.The conventional group was given symptomatic treatment by Western medicine, while the observation group was given Blood Mansion Stasis-Expelling Decoction on the basis of the conventional group.Barthel index, Hamilton depression scale(HAMD) score, Hamilton anxiety scale(HAMA) score, functional comprehensive assessment(FCA) score, protein metabolism and neuroendocrine regulation of patients were observed before and after treatment.Results: The Barthel index and FCA score in the two groups were higher than those before treatment 2 weeks after treatment, and the Barthel index and FCA score in the observation group were higher than those in the control group 2 weeks after treatment, with statistically significant differences(P<0.05).The HAMD score and HAMA score in the two groups were lower than those before treatment 2 weeks after treatment, and the HAMD score and HAMA score in the observation group were lower than those in the control group 2 weeks after treatment, with statistically significant differences(P<0.05).The levels of adrenocorticotropic hormone(ACTH),thyroid stimulating hormone(TSH) and prolactin(PRL) in the two groups were lower than those before treatment 2 weeks after treatment, and the levels of ACTH,TSH and PRL in the observation group were lower than those in the control group 2 weeks after treatment, with statistically significant differences(P<0.05).The levels of serum prealbumin, albumin and transferrin in the two groups were higher than those before treatment 2 weeks after treatment, and the levels of serum prealbumin, albumin and transferrin in the observation group were higher than those in the control group 2 weeks after treatment, with statistically significant differences(P<0.05).Conclusion: Blood Mansion Stasis-Expelling Decoction combined with conventional Western medicine can promote the recovery of patients′ ability of daily living, improve their comprehensive functional ability, and better the body protein metabolism and neuroendocrine regulation.