临床药师干预降低医院抗生素不合理应用率的效果分析

Analysis of the effect of clinical pharmacist intervention in reducing the irrational application rate of antibiotics in hospitals

目的 探究临床药师干预降低医院抗生素不合理应用率的效果。方法 随机选取2021年1~12月实施临床药师干预的100例需要采取抗生素治疗的患者作为观察组,另选取2020年1~12月未开展临床药师干预仅单纯采取常规用药指导的需要采取抗生素治疗的100例患者作为对照组。对比两组患者抗生素不合理使用情况,用药后不良反应发生情况。结果 观察组患者的抗生素随机选取不合理、未经实验室培养给药、用药剂量不合理、联合用药不当、用药周期短发生率分别为7.00%、5.00%、3.00%、2.00%、1.00%,均显著低于对照组的16.00%、13.00%、10.00%、9.00%、7.00%,差异具有统计学意义(P<0.05)。观察组患者的用药后不良反应发生率为11.00%,显著低于对照组的34.00%,差异具有统计学意义(P<0.05)。结论 通过临床药师干预能够显著降低医院抗生素不合理应用率,对抗生素规范使用具有显著促进作用,可以降低不良反应发生率,取得满意的干预效果。

Objective To investigate the effect of clinical pharmacist intervention in reducing the irrational application rate of antibiotics in hospitals. Methods 100 patients requiring antibiotic treatment from January to December 2021 who implemented clinical pharmacist intervention were randomly selected as the observation group, and the 100 patients who needed to take antibiotic treatment from January to December 2020 who did not carry out clinical pharmacist intervention but took the conventional medication instruction alone were selected as the control group. The irrational application rate and the occurrence of adverse reactions after medication were compared between the two groups. Results The incidence of irrational random selection of antibiotics, administration without laboratory culture, irrational dose, inappropriate drug combination, and short medication cycle in the observation group were 7.00%, 5.00%, 3.00%, 2.00%, and 1.00%, which were significantly lower than 16.00%, 13.00%, 10.00%, 9.00%, and 7.00% in the control group, and the difference were statistically significant(P<0.05). The incidence of adverse reactions after medication in the observation group was 11.00%, which was significantly lower than 34.00% in the control group, and the difference was statistically significant(P<0.05). Conclusion The clinical pharmacist intervention can significantly reduce the irrational application rate in hospitals, which can significantly promote the standard use of antibiotics, reduce the incidence of adverse reactions, and achieve satisfactory intervention effects.