地榆止血汤辅助对高危急性非静脉曲张性上消化道出血患者止血有效率的影响

Effect of diyu Zhixue decoction on the Effective Rate of Hemostasis in High-risk Patients with Acute Non-Variceal Upper Gastrointestinal Bleeding

目的:探究地榆止血汤辅助西药治疗胃热炽盛型高危急性非静脉曲张性上消化道出血患者的临床疗效,及对血液流变学、炎性因子水平的影响。方法:随机数字表法将符合标准的98例胃热炽盛型高危急性非静脉曲张性上消化道出血患者分为对照组(n=49)、联合组(n=49)。对照组予以西药治疗,联合组于对照组基础上加用地榆止血汤治疗。观察2组治疗效果、临床相关指标,对比治疗前后红细胞分布宽度(RDW)、红细胞比容(HCT)、血小板计数(PLT)、血液流变学、血清炎性因子水平。结果:联合组总有效率(97.96%)高于对照组(83.67%)(P<0.05);联合组止血时间、住院时间较对照组短,输血量较对照组低(P<0.05);治疗后2组HCT、RDW、PLT较治疗前上升,且联合组高于对照组(P<0.05);治疗后2组血浆黏度、全血低切黏度、全血高切黏度较治疗前上升,且联合组高于对照组(P<0.05);治疗后2组血清白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)水平较治疗前降低,且联合组低于对照组(P<0.05)。结论:地榆止血汤辅助治疗高危急性非静脉曲张性上消化道出血患者能减轻炎症反应,改善血液流变学,增强止血效果,促进病情恢复。

Objective: To explore the clinical curative effect of Diyu Zhixue Decoction combined with western medicine in the treatment of high-risk patients with acute non-variceal upper gastrointestinal bleeding of stomach heat type,and its effect on blood rheology and inflammatory factor levels. Methods: 98 high-risk patients with acute non-variceal upper gastrointestinal bleeding who met the standard were divided into control group(n=49) and combined group(n=49)by random number table method. The control group was treated with western medicine, and the combination group was additionally treated with Diyu Zhixue Decoction on the basis of the control group. The treatment effect and clinical related indicators of the two groups were observed, and red blood cell distribution width(RDW), hematocrit(HCT),platelet count(PLT), blood rheology, and serum inflammatory factor levels were compared before and after treatment.Results: The total effective rate of the combination group(97.96%) was higher than that of the control group(83.67%)(P<0.05);the hemostasis time and hospitalization time of the combination group were shorter than those of the control group, and the amount of blood transfusion was lower than that of the control group(P<0.05);HCT, RDW, and PLT in the latter two groups were higher than those before treatment, and those in the combined group were higher than those in the control group(P<0.05);after treatment, the plasma viscosity, whole blood low shear viscosity, and whole blood high shear viscosity in the two groups were higher than those before treatment, and The combination group was higher than that of the control group(P<0.05);after treatment, the levels of serum interleukin-6(IL-6), hypersensitive Creactive protein(hs-CRP), procalcitonin(PCT), tumor necrosis factor-α(TNF-α) level was lower than that before treatment, and the combined group was lower than the control group(P<0.05). Conclusion: Diyu Zhixue Decoction as adjuvant therapy for high-risk patients with acute non-variceal upper gastrointestinal bleeding can reduce inflammation, improve hemorheology, enhance hemostatic effect, and promote recovery.