运动改善抑郁症认知功能障碍的机制研究进展

Research progress on the mechanisms of exercise improving cognitive dysfunction in major depressive disorder

抑郁症患者认知功能障碍症状恢复困难,严重制约患者的全面功能康复,而现有抗抑郁药物治疗对认知功能改善作用有限。运动作为抑郁症重要的非药物疗法具有潜在的改善认知功能作用,但其具体作用机制仍不明确。本文梳理和总结运动干预改善抑郁症认知功能障碍的生物学机制,发现运动可改善相关脑区功能,经脑源性神经营养因子、血管内皮细胞生长因子、犬尿氨酸代谢通路、神经炎症、脂联素等多种途径促进中枢神经系统神经可塑性,以及治疗躯体症状,最终改善认知功能。

The difficulty in the recovery of cognitive symptoms severely restricts the functional rehabilitation of patients with major depressive disorder,while the cognitive improvement of existing antidepressant therapy is limited.Exercise,as an important non-drug therapy for major depressive disorder in recent years,has a potential cognitive improvement effect.However,the specific mechanism of exercise is still unclear.This review summarizes the biological mechanisms by which exercise intervention improves cognitive dysfunction in major depressive disorder and finds that exercise can improve the function of related brain areas,promote neuronal plasticity in many ways,and treat physical symptoms,thus improving cognitive performance.