血清β-Hcg、孕酮在宫外孕患者诊断中的临床价值

Analysis of serum β-Hcg and Progesterone in the diagnostic value of patients with ectopic pregnancy

目的分析血清β-人绒毛膜促性腺激素(β-Hcg)、孕酮(P)在宫外孕患者诊断中的临床价值。方法选择成都市第三人民医院收治的宫外孕孕妇149例作为宫外孕组,选择同期于医院检查的100例正常妊娠孕妇作为正常妊娠组,比较两组孕妇不同孕周血清β-Hcg、P水平,并比较不同血清β-Hcg水平宫外孕患者的治疗方案以及治疗效果。结果宫外孕组孕妇4^(+)周、5^(+)周、6^(+)周和7^(+)周血清β-Hcg、P水平明显低于正常妊娠组孕妇(P<0.05);血清β-Hcg<5000U/L以药物保守治疗为主(81.51%),血清β-Hcg≥5000U/L以手术治疗为主(60.00%),不同血清β-Hcg水平宫外孕患者治疗方案比较,差异有统计学意义(P<0.05);血清β-Hcg≥5000U/L时药物保守治疗成功率明显低于血清β-Hcg<5000U/L时的治疗成功率(P<0.05),手术治疗成功率比较,差异无统计学意义(P>0.05)。结论宫外孕孕妇血清β-Hcg、P水平明显低于正常妊娠孕妇,可作为宫外孕诊断的有效参考指标,对于血清β-Hcg≥5000U/L的患者建议优先考虑手术治疗,或者在严密监测下进行药物保守治疗,必要时及时进行手术治疗,血清β-Hcg水平对于宫外孕患者治疗方案的选择具有一定的指导价值。

Objective To analyze the diagnostic value of serum β-human chorionic gonadotropin(β-Hcg)and progesterone(P)on patients with ectopic pregnancy.Methods 149 pregnant women with ectopic pregnancy who were admitted to the hospital were selected as the ectopic pregnancy group,and 100 normal pregnant women who were examined in the hospital during the same period were enrolled as the normal pregnancy group.Serum β-Hcg and P levels at different gestational weeks.The treatment regimen and therapeutic effects of patients with ectopic pregnancy with different serum β-Hcg levels were compared.Results The levels of serum β-Hcg and P of pregnant women in the ectopic pregnancy group at 4^(+)weeks,5^(+)weeks,6^(+)weeks and 7^(+)weeks were significantly lower than those in the normal pregnancy group(P<0.05).Serum β-Hcg<5000U/L group was mainly given conservative drug treatment(81.51%),and serum β-Hcg≥5000U/L group was mainly treated with surgery(60.00%),and the difference was statistically significant in the comparison of treatment regimen of patients with ectopic pregnancy with different serum β-Hcg levels(P<0.05).The success rate of conservative drug treatment of serum β-Hcg≥5000U/L was significantly lower than that of serum β-Hcg<5000U/L(P<0.05),but there was no statistical significance in the success rate of surgical treatment(P>0.05).Conclusion The levels of serum β-Hcg and P of pregnant women with ectopic pregnancy are significantly lower than those of normal pregnant women,which can be used as effective reference indicators for the diagnosis of ectopic pregnancy.For patients with serum β-Hcg≥5000U/L,it is recommended to give priority to surgical treatment,or to carry out conservative drug treatment under close monitoring and give timely surgical treatment if necessary.Serum β-Hcg level has certain guiding value for the selection of the treatment regimen for patients with ectopic pregnancy.