八段锦与有氧运动训练对稳定期慢性阻塞性肺疾病患者肺康复效果及免疫功能的影响

Influence of Baduanjin and aerobic training on pulmonary rehabilitation and immune function in patients with stable chronic obstructive pulmonary diseases

目的对比八段锦与有氧运动训练两种不同康复模式对稳定期慢性阻塞性肺疾病(COPD)患者肺康复效果与免疫功能的影响。方法前瞻性纳入就诊的180例COPD稳定期患者作为研究对象,随机分为八段锦组和对照组。在COPD标准化治疗的基础上,八段锦组采用八段锦康复训练,对照组采用有氧踏车运动训练,治疗6个月。并对患者每3个月进行1次全面评估,通过比较两组患者肺功能、6 min步行试验(6MWT)距离、COPD评估测试问卷评分(CAT评分)、Borg评分、AD评分,评价肺康复效果。通过检测血中CD3、CD4、CD8水平,比较两组患者的免疫功能。结果干预前八段锦组肺功能第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、第1秒用力肺活量占预计值的百分比(FEV_(1)%)与对照组比较,差异均无统计学意义(P>0.05);治疗后3个月、6个月八段锦组肺功能明显优于治疗前以及对照组(P<0.05)。干预前八段锦组6MWT、CAT评分、Borg评分、AD评分与对照组比较,差异无统计学意义(P>0.05);干预后3个月、6个月八段锦组6MWT、CAT评分、Borg评分、AD评分明显优于对照组(P<0.05);且6个月时各项指标均优于治疗3个月时(P<0.05)。干预前八段锦组CD3、CD4、CD8水平与对照组比较,差异无统计学意义(P>0.05),干预后3个月、6个月八段锦组CD3、CD4水平明显升高,CD8水平明显降低,与对照组比较,差异有统计学意义(P<0.05);6个月时CD3、CD4水平均优于治疗3个月时(P<0.05)。结论将八段锦应用于稳定期COPD患者的肺康复训练中并长期坚持下去,可明显提高患者的肺康复效果并改善患者的免疫功能指标。

Objective To observe the effects of different rehabilitation modes of Baduanjin and aerobik training on the pulmonary rehabilitation and immune function of patients with stable chronic obstructive pulmonary disease(COPD).Methods A total of 180 patients with stable COPD were randomly selected and randomly divided into Baduanjin group and control group.On the basis of standardized treatment of COPD,all patients were treated with aerobic exercise training in the control group,while the patients in Baduanjin group were treated with Baduanjin rehabilitation training for 6 months.The patients were evaluated every three months.The pulmonary rehabilitation effect of patients was evaluated according to the lung function,6-minute walk test(6MWT),CAT score,Borg score,and AD score.The immune function of the patients in the two groups was compared by assessing the levels of CD3,CD4,and CD8 in blood.Results There was no significant difference in pulmonary function between the two groups before treatment(P>0.05);while 3 months and 6 months after treatment,the lung functions of the Baduanjin group were significantly better than those before treatment and the control group(P<0.05).Before intervention,the 6MWT,CAT score,Borg score,and AD score of the Baduanjin group were not significantly different from those of the control group(P>0.05).The 6MWT,CAT score,Borg score and AD score were significantly better in the Baduanjin group than the control group 3 and 6 moths after intervention(P<0.05).Before intervention,the CD3,CD4,and CD8 levels of the Baduanjin group were not significantly different from those of the control group(P>0.05).The CD3 and CD4 levels of the Baduanjin group were significantly increased and the CD8 levels were significantly reduced 3 months and 6 months after treatment(P<0.05).Conclusion Applying Baduanjin to the pulmonary rehabilitation training of patients with stable COPD can significantly improve the patient′s pulmonary rehabilitation effect and improve the patient′s immune function.