炎症性肠病患儿HP感染与GAS、chemerin和CHE的关系

Relationship between HP infection and GAS,chemerin and CHE in children with inflammatory bowel disease

目的探究炎症性肠病(IBD)患儿幽门螺杆菌(HP)感染与血清胃泌素(GAS)、脂肪细胞因子(chemerin)、胆碱酯酶(CHE)水平的关系。方法选取2019年6月至2020年12月于颍上县人民医院就诊的106例IBD患儿,根据HP感染情况分为感染组22例与未感染组84例。比较两组血清GAS、chemerin、CHE水平,采用Logistic回归分析模型分析血清GAS、chemerin、CHE水平与IBD患儿HP感染的关系,采用受试者工作特征曲线(ROC)评估上述指标对IBD患儿HP感染的诊断效能。结果感染组血清GAS、chemerin水平显著高于未感染组,CHE水平显著低于未感染组,差异均有统计学意义(P<0.05)。Logistic回归分析显示,血清GAS、chemerin、CHE水平与IBD患儿HP感染具有显著相关性(P<0.05)。GAS、chemerin、CHE诊断IBD患儿HP感染的ROC曲线AUC分别为0.788、0.857、0.917,截断值分别为152.52 pg/mL、119.89μg/L、6233.64 U/L,诊断效能良好(P<0.05)。结论血清GAS、chemerin、CHE水平诊断IBD患儿HP感染效能良好,可为IBD患儿HP感染诊断提供参考。

Objective To explore the relationship between Helicobacter pylori(HP)infection and levels of serum gastrin(GAS),adipocytokine(chemerin)and cholinesterase(CHE)in children with inflammatory bowel disease(IBD).Methods 106 children with IBD who were treated in the People's Hospital of Yingshang were selected between June 2019 and December 2020.According to the HP infection,the children were divided into 22 cases in the infected group and 84 cases in the uninfected group.The levels of serum GAS,chemerin and CHE were compared between the two groups.Logistic regression analysis model was used to analyze the relationship between levels of serum GAS,chemerin and CHE and HP infection in children with IBD,and receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficiency of the above indicators on HP infection in children with IBD.Results The levels of serum GAS and chemerin in the infected group were significantly higher than those in the uninfected group while the level of CHE was significantly lower than that in the uninfected group(P<0.05).Logistic regression analysis showed that the levels of serum GAS,chemerin and CHE were significantly correlated with HP infection in children with IBD(P<0.05).The AUC values of ROC curves of the above indicators in the diagnosis of HP infection in children with IBD were 0.788,0.857 and 0.917,and the cut⁃off values were 152.52 pg/mL,119.89μg/L and 6233.64 U/L respectively,with good diagnostic efficiency(P<0.05).Conclusion The levels of serum GAS,chemerin and CHE have good efficiency in diagnosing HP infection in children with IBD,and can provide a reference for the diagnosis of HP infection in children with IBD.