紫杉醇脂质体联合铂类化疗同步放疗在宫颈癌中的应用及对CA125、TA⁃4、SCC水平及预后的影响

Application of paclitaxel liposome combined with platinum⁃based chemotherapy and concurrent radiotherapy in cervical cancer and its effects on CA125,TA⁃4,SCC levels and prognosis

目的分析紫杉醇脂质体联合铂类同步放化在宫颈癌中的应用价值及对糖类抗原⁃125(CA125)、肿瘤抗原⁃4(TA⁃4)、鳞状上皮细胞癌抗原(SCC)水平及预后的影响。方法选取2019年5月至2021年5月期间唐山市弘慈医院接收的106例宫颈癌患者,根据不同治疗方法分为观察组(紫杉醇脂质体联合铂类化疗同步放疗,n=54)和对照组(紫杉醇和顺铂化疗同步放疗,n=52)。比较两组的临床疗效、CA125、TA⁃4、SCC水平的变化、1年内生存率、毒副反应和生活质量。结果观察组的临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后两组CA125、TA⁃4、SCC⁃Ag水平均降低,观察组下降更为明显,差异有统计学意义(P<0.05)。治疗后观察组生活质量优于对照组,差异有统计学意义(P<0.05)。观察组1年生存率高于对照组,毒副反应发生率低于对照组,差异有统计学意义(P<0.05)。结论紫杉醇脂质体联合铂类同步放化在宫颈癌中的应用价值高,能有效提高患者的生存率,减少毒副反应的发生。

Objective To analyze the application value of paclitaxel liposome combined with simultaneous platinum⁃based radiochemistry in cervical cancer and its effects on carbohydrate antigen⁃125(CA125),tumor antigen⁃4(TA⁃4),squamous cell carcinoma antigen(SCC)levels and prognosis.Methods 106 cervical cancer patients admitted to Tangshan Hongci Hospital from May 2019 to May 2021 were selected as the research objects,and according to different treatment methods,they were divided into the observation group(paclitaxel liposome combined with platinum⁃based chemotherapy and concurrent radiotherapy,n=54)and the control group(paclitaxel and cisplatin chemotherapy and concurrent radiotherapy,n=52).The clinical efficacy,the changes of CA125,TA⁃4 and SCC levels,1⁃year survival rate,toxic and side effects and quality of life of the two groups of patients were compared.Results The total clinical effective rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CA125,TA⁃4 and SCC⁃Ag in the two groups were decreased,and the decrease was more obvious in the observation group,and the difference was statistically significant(P<0.05).After treatment,the quality of life in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).The 1⁃year survival rate of the observation group was higher than that of the control group,and the incidence of side effects of the observation group was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Paclitaxel liposome combined with platinum⁃based simultaneous radiochemotherapy has high application value in cervical cancer,which can effectively improve the survival rate of patients and reduce the occurrence of toxic and side effects.