摘要
目的探讨前列地尔联合维生素D在糖尿病足溃疡患者中的应用效果。方法选取2020年1月至2021年12月莆田学院附属医院内分泌科收治的68例糖尿病足溃疡患者作为研究对象,采用随机数字法将其分为观察组和对照组,每组各34例。观察组患者采用前列地尔联合维生素D治疗,对照组患者采用前列地尔治疗。比较两组患者的临床治疗效果、创面面积、局部疼痛程度变化情况、炎症因子水平变化情况、创面愈合时间。结果治疗后,观察组患者的临床治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗前,两组患者的创面面积、视觉模拟评分法(VAS)比较,差异无统计学意义(P>0.05);治疗后,两组患者的创面面积、VAS评分均低于治疗前,且观察组患者的创面面积、VAS评分低于对照组,差异有统计学意义(P<0.05);治疗前,两组患者的白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、C反应蛋白(CRP)比较,差异无统计学意义(P>0.05);治疗后,两组患者的IL-6、TNF、CRP均低于治疗前,且观察组患者的IL-6、TNF、CRP低于对照组,差异有统计学意义(P<0.05)。结论前列地尔联合维生素D治疗糖尿病足溃疡患者,其对清除创面、缩小创面面积、减轻局部疼痛度、降低炎症因子水平表现出良好效果,临床疗效显著,值得应用。
Objective To investigate the application effect of Alprostadil combined with Vitamin D in patients with diabetic foot ulcer.Methods A total of 68 patients with diabetes foot ulcer in the Department of Endocrinology of the Affiliated Hospital of Putian University from January 2020 to December 2021 were selected as the research objects.They were divided into observation group and control group by random number method,with 34 patients in each group.The observation group was treated with Alprostadil combined with Vitamin D,and the control group was treated with Alprostadil.The clinical treatment effect,wound area,local pain degree,inflammatory factor level and wound healing time were compared between the two groups.Results After treatment,the total effective rate of observation group was higher than that of control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the wound area and visual analogue scale(VAS)between the two groups(P>0.05).After treatment,the wound area and VAS score of the two groups were lower than those before treatment,and the wound area and VAS score of the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in interleukin-6(IL-6),tumor necrosis factor(TNF)and C-reactive protein(CRP)between the two groups(P>0.05).After treatment,the levels of IL-6,TNF and CRP in the two groups were lower than those before treatment,and the levels of IL-6,TNF and CRP in observation group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion In the treatment of diabetic foot ulcer patients,Alprostadil combined with Vitamin D has shown good effect on wound clearance,wound area reduction,local pain reduction and reduction of inflammatory factor levels.The clinical efficacy is significant,and it is worthy of application.
作者
林妹
LIN Mei(Department of Endocrinology,Affiliated Hospital of Putian University,Fujian Province,Putian351100,China)
出处
《中国当代医药》
CAS
2023年第2期77-80,共4页
China Modern Medicine