摘要
目的探讨三阴性乳腺癌预后的影响因素。方法选取2015年5月至2018年8月江南大学附属医院收治的96例三阴性乳腺癌术后患者作为研究对象。根据体重指数(BMI)将其分为正常或低体重组(n=41)和超重或肥胖组(n=55),正常或低体重组患者的BMI<23 kg/m^(2),超重或肥胖组患者的BMI≥23 kg/m^(2)。比较两组患者的体重指数和临床病理特征与无疾病生存及总体生存的相关性。结果两组患者的BMI值比较,差异有统计学意义(P=0.039)。正常或低体重组和超重或肥胖组5年无疾病生存率分别为80.7%和59.7%(P=0.039),5年总体生存率分别为79.0%和79.7%(P=0.890)。单因素分析结果显示,T分期、N分期、BMI是影响三阴性乳腺癌术后患者无疾病生存的预后因素(P<0.05),T分期、分化程度是影响总体生存的预后因素(P<0.05)。多因素分析结果显示,N分期和BMI是影响患者无疾病生存的独立预后因素(P<0.05),分化程度是影响患者总体生存的独立预后因素(P<0.05)。结论与正常或低体重组三阴性乳腺癌患者相比,超重或肥胖组的患者具有更高的复发转移率,建议三阴性乳腺癌患者控制体重。
Objective To investigate the prognostic factors of triple negative breast cancer.Methods A total of 96 patients with triple negative breast cancer in Affiliated Hospital of Jiangnan University from May 2015 to August 2018 were selected as research objects.They were divided into normal or low weight group(n=41)and overweight or obese group(n=55)according to body mass index(BMI).Patients in the normal or low weight group had a BMI of<23 kg/m^(2),and those in the overweight or obese group had a BMI of≥23 kg/m^(2).The relationship between body mass index and clinicopathological features,disease free survival and overall survival was compared between the two groups.Results There was a significant difference in BMI between the two groups(P<0.05).The 5-year disease free survival were 80.7%and 59.7%for patients with normal or low body weight and overweight or obese,respectively(P=0.039).And the 5-year overall survival were 79.0%and 79.7%for patients normal or low body weight and overweight or obese,respectively(P=0.890).Univariate analysis revealed that T stage,N stage and BMI were the prognostic factors for disease free survival(P<0.05).And T stage and differentiation were the prognostic factors for overall survival(P<0.05).Multivariate analysis demonstrated that N stage and BMI were the independent prognostic factors for disease free survival(P<0.05).And differentiation was the independent prognostic factors for overall survival(P<0.05).Conclusion Triple-negative breast cancer patients with overweight or obese had higher recurrence and metastasis rates compared with counterpart with normal or low body weight.Control weight was recommended for triple-negative breast cancer patients with overweight or obese.
作者
杨开华
YANG Kaihua(Department of Radiotherapy and Oncology,Affiliated Hospital of Jiangnan University,Jiangsu Province,Wuxi214000,China)
出处
《中国当代医药》
CAS
2023年第2期109-113,共5页
China Modern Medicine
关键词
体重指数
三阴性乳腺癌
预后
总体生存
无疾病进展生存
Body mass index
Triple negative breast cancer
Prognosis
Overall survival
Disease free survival