玉屏风颗粒联合西药治疗在慢性阻塞性肺疾病稳定期患者中的应用效果

Application effect of Yupingfeng Granule combined with Western medicine treatment in patients with chronic obstructive pulmonary disease in stable stage

目的探讨慢性阻塞性肺疾病(COPD)稳定期患者采用玉屏风颗粒联合西药治疗的效果。方法选取2019年1月至2021年12月罗湖区人民医院收治的100例COPD患者作为研究对象,按照随机数字表法分为观察组(50例,玉屏风颗粒联合西药治疗)与对照组(50例,西药治疗),均治疗12周。评估两组患者治疗效果,比较两组患者治疗前后的肠道菌群失调率、炎症因子水平及肺功能,统计两组患者不良反应。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者肠道菌群失调率均低于治疗前,且观察组肠道菌群失调率低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者C反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)水平均低于治疗前,且观察组CRP、TNF-α低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者第1秒用力呼吸容积(FEV1)、最大呼气流量(PEF)及最大肺活量(FVC)水平均高于治疗前,且观察组FEV1、PEF、FVC水平高于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均无不良反应。结论COPD稳定期患者采用玉屏风颗粒联合西药治疗效果满意,可调节肠道菌群及炎症因子水平,改善肺功能,且安全性好。

Objective To explore the effect of Yupingfeng Granule combined with Western medicine in patients with chronic obstructive pulmonary disease(COPD)in stable stage.Methods A total of 100 patients with COPD treated in Luohu People's Hospital from January 2019 to December 2021 were selected as research objects,they were divided into observation group(50 cases,treated with Yupingfeng Granule combined with Western medicine)and control group(50 cases,treated with Western medicine)according to the random number table method,both groups were treated for 12 weeks.Evaluate the treatment effect of the two groups,compare the intestinal flora imbalance,inflammatory factor level and lung function of the two groups before and after treatment,and recorded the adverse reactions of the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the intestinal flora imbalance rate of the two groups was lower than that before treatment,and the intestinal flora imbalance rate of the observation group was lower than that of the control group,with statistical significances(P<0.05).After treatment,C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)levels in two groups were lower than those before treatment,and CRP and TNF-αlevels in the observation group were lower than those of control group,with statistical significances(P<0.05).After treatment,the levels of forced respiration volume in one second(FEV1),peak expiratory flow(PEF)and forced vital capacity(FVC)of the two groups were higher than those before treatment,and FEV1,PEF and FVC levels in the observation group were higher than those in the control group,with statistical significances(P<0.05).There were no adverse reactions in both groups during treatment.Conclusion Yupingfeng Granule combined with Western medicine is effective in the treatment of patients with COPD in stable stage,which can adjust the level of intestinal flora and inflammatory factors,improve lung function,and has good safety.