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IDH1和VEGF对非小细胞肺癌的诊断意义

Diagnostic significance of IDH1 and VEGF in non⁃small cell lung cancer
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摘要 目的分析非小细胞肺癌(NSCLC)患者血清异柠檬酸脱氢酶1(IDH1)和血管内皮生长因子(VEGF)的表达变化及临床意义。方法选取2020年1月至2021年10月我院收治经肺穿刺和支气管镜活检经病理学检查后确诊和暂未接受抗癌治疗的NSCLC患者56例。抽取静脉血检测IDH1和VEGF,分析IDH1和VEGF水平与NSCLC患者临床病理特征关系。结果NSCLC患者IDH1和VEGF水平分别为(13.05±5.25)ng/ml和(312.75±102.07)pg/ml。IDH1和VEGF表达水平与TNM分期、肿瘤分化程度、有无淋巴结转移和CEA水平相关(P<0.05)。ROC曲线分析显示:IDH1、VEGF及二者联合对NSCLC的诊断曲线下面积(AUC)分别为0.791,0.779和0.876,敏感性分别为68.50%,75.55%和82.25%,特异性分别为87.25%,78.75%和90.05%。结论IDH1和VEGF水平中NSCLC患者中表达升高,与肿瘤的增殖和侵袭迁移关系密切,对NSCLC的早期诊断具有临床意义。
作者 王玉芹 刘冠群 曲福君 Wang Yuqin;Liu Guanqun;Qu Fujun
机构地区 青岛市市立医院(东院)急诊科
出处 《中华肺部疾病杂志（电子版）》 2022年第6期847-849,共3页 Chinese Journal of Lung Diseases(Electronic Edition)
关键词 非小细胞肺癌 异柠檬酸脱氢酶1 血管内皮生长因子
分类号 R734.2 [医药卫生—肿瘤]
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中华肺部疾病杂志（电子版）
2022年 第6期

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