摘要
Lysosomes are ubiquitous and dynamic organelles with a central role in degradation and recycling of damaged cell components and misfolded proteins,otherwise known as autophagy.Autophagy plays a fundamental role in the process of correcting cell homeostasis and cellular survival.Unsurprisingly,this process is essential in the central nervous system,as neurons are not able to easily eliminate altered proteins given their post-mitotic state.
基金
supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)(No.125440785–SFB877,project B11)
by the Interdisciplinary Center for Clinical Research(IZKF)at the University Hospital of the University of Erlangen-Nuremberg(Jochen-Kalden funding program N8)(both to FZ)。
