摘要
卒中后认知障碍是卒中的重要后遗症之一,从病理上可以分为血管性、退变性及混合性认知障碍。水通道蛋白4广泛分布于中枢神经系统,参与多种神经系统疾病和认知障碍的病理过程,但其参与卒中后认知障碍的具体机制目前尚未明确。本文综述水通道蛋白4通过参与调节神经炎症、突触可塑性以及β-淀粉样蛋白的积聚和清除过程在卒中后认知障碍中发挥的可能作用。
Post-stroke cognitive impairment is one of the main sequelae of stroke,which can be divided into vascular,degenerative and mixed cognitive impairment.Aquaporin 4 is widely distributed in the central nervous system and is involved in the pathological process of cognitive impairment and multiple nervous system diseases.However,the specific mechanism of aquaporin 4 in post-stroke cognitive impairment is not clear.This article reviewed the possible important role of aquaporin 4 in post-stroke cognitive impairment by involvement in the regulation of neuroinflammation,synaptic plasticity,and the accumulation and clearance ofβ-amyloid.
作者
梁潇
钱海兵
LIANG Xiao;QIAN Haibing(Guizhou University of Traditional Chinese Medicine,Guizhou Provincial Research Center for Consistency of Effectiveness of Authentic Medicinal Materials,Guiyang 550025,China)
出处
《中国卒中杂志》
2022年第12期1385-1390,共6页
Chinese Journal of Stroke
基金
贵州省普通高等学校特色重点实验室项目(黔教合KY字[2017]006)
贵州省优秀科技教育人才省长专项资金项目[黔省专合字(2012)167号]。
