基于Wnt/β-catenin信号通路的中医药防治骨质疏松症研究进展

Research Progress of the Prevention and Treatment of Osteoporosis with Traditional Chinese Medicine Based on Wnt/β-Catenin Signaling Pathway

目的为中医药防治骨质疏松症提供参考。方法以“Wnt/β-catenin信号通路”“骨质疏松症”“中医药”为关键词,检索国内外数据库中相关文献,分别探讨骨质疏松症的发病机制、Wnt/β-catenin信号通路与骨质疏松症的关系及中医药基于Wnt/β-catenin信号通路防治骨质疏松症的研究进展。结果Wnt/β-catenin信号通路与骨质疏松症的发生密切相关。现阶段关于中医药防治骨质疏松症的研究较广泛,组方中应用频次较高的中药包括熟地黄、淫羊藿、黄芪、骨碎补、补骨脂,其中大部分被证实可通过调控Wnt信号通路或下游靶基因表达促进骨形成和骨矿化。结论以Wnt/β-catenin信号通路为切入点研究骨质疏松症的防治,可为该病的中医药治疗和中药研发提供一定的理论依据。

Objective To provide a reference for the prevention and treatment of osteoporosis with traditional Chinese medicine (TCM). Methods With the keywords of ″Wnt / β - catenin signaling pathway″ ″osteoporosis″ and ″TCM″,the relevant literature in domestic and foreign databases were searched to elaborate the pathogenesis of osteoporosis,the relationship between Wnt / β - catenin signaling pathway and osteoporosis,and the research progress of TCM in the prevention and treatment of osteoporosis based on Wnt / β - catenin signaling pathway. Results Wnt / β - catenin signaling pathway is closely related to the occurrence of osteoporosis. At present,the research on the prevention and treatment of osteoporosis with TCM is relatively extensive. The TCM with the high frequency of application in the formulation includes Rehmanniae Radix Preparata,Epimedii Folium,Astragali Radix, Drynariae Rhizoma,and Psoraleae Fructus,and most of them are confirmed to promote bone formation and mineralization by regulating Wnt signaling pathway or downstream target gene expression. Conclusion Taking the prevention and treatment of osteoporosis with TCM through the Wnt / β - catenin signaling pathway as the breakthrough point,it is can provide a theoretical basis for the treatment of this disease with TCM and the research and development of TCM.