外泌体与疼痛关系的研究进展

Research progress on the relationship between exosomes and pain

外泌体是与细胞间通讯有关的细胞外微囊泡,具有转运和传递生物大分子的能力。疼痛将导致患者的生活质量急剧下降,给患者和社会产生沉重的医疗负担。越来越多的证据表明,外泌体在疼痛相关疾病病理过程中起着重要作用。对不同疼痛条件下外泌体及其所运载生物分子进行总结,识别与疼痛状态相关的特定外泌体表征将有助于对疼痛相关疾病进行早期诊断和对因治疗。此外,外泌体传递信息的能力及其在机体广泛存在的特性表明,其在疼痛领域作为新型诊疗工具具有广阔前景。更好地了解外泌体与疼痛之间的关系将给疼痛患者提供一种新颖而有前途的治疗方法。

Exosomes are extracellular microbubbles related to intercellular communication,which have the ability to transport and transfer biological macromolecules.Pain will lead to a sharp decline in the quality of life of patients,and will give patients and society a heavy medical burden.More and more evidences show that the exosomes plays an important role in the pathological process of pain related diseases.Summarizing the exosomes and the biomolecules carried by them under different pain conditions,and identifying the specific exosomes related to the pain state will be helpful for early diagnosis and treatment of pain related diseases.In addition,the ability of exosomes to transmit information and its widespread characteristics in the body indicate that they have broad prospects as a new diagnosis and treatment tool in the field of pain.A better understanding of the relationship between the exosomes and pain will provide a novel and promising treatment for patients with pain.