缺氧信号通路在肾癌中的研究进展

Research progress of hypoxia signal pathway in renal cell carcinoma

缺氧是实体肿瘤微环境的一个重要的基本特征,随着人们对肾细胞癌(RCC)发病机制研究的不断深入,缺氧和低氧诱导因子(HIF)在人肾癌中的表达及其功能越来越被关注,缺氧信号通路成为近年来肿瘤等疾病的研究热点。本文综述了目前对缺氧信号通路的认识、其与RCC发生发展的相关性以及HIF抑制剂的应用前景,以期指导临床RCC的精准化治疗。

Hypoxia is an important basic feature of the solid tumor microenvironment.With the deepening of the research on the pathogenesis of renal cell carcinoma(RCC),the expression and function of hypoxia and hypoxia inducible factor(HIF)in RCC have attracted more and more attention.The hypoxia signal pathway has become a research hotspot of tumor and other diseases in recent years.This article reviews the current understanding of hypoxia signal pathway,its correlation with the occurrence and development of RCC,and the application prospect of HIF inhibitors,in order to guide the precise treatment of clinical RCC.