摘要
DDX5解螺旋酶(DEAD box helicases 5)又名P68,是一类依赖ATP的RNA解螺旋酶中重要成员之一。研究表明,DDX5在多种癌症中异常表达,靶向多种肿瘤相关的信号通路,调控上下游的因子从而影响肿瘤细胞的发生、侵袭及迁移。本文阐述DDX5在恶性肿瘤的生物学作用,为肿瘤的靶向治疗提供可能方向。
DDX5 helicase(DEAD box helicases 5),also known as P68,is an important member of an ATP dependent RNA helicase.Studies have shown that DDX5 is abnormally expressed in a variety of cancers,targeting a variety of tumor related signal pathways,regulating upstream and downstream factors to affect the occurrence,invasion and migration of tumor cells.This article describes the biological role of DDX5 in malignant tumors and provides prospects for targeted treatment of tumors.
作者
刘郭琦
黄玉梅
宋娇娇
王文龙
马向瑞
于成龙
左金华
Liu Guoqi;Huang Yumei;Song Jiaojiao;Wang Wenlong;Ma Xiangrui;Yu Chenglong;Zuo Jinhua(Department of Oral and Maxillofacial Surgery,Affiliated Hospital to Binzhou Medical University,Binzhou 256699,China;Department of Oral Rehabilitation,Affiliated Hospital to Binzhou Medical University,Binzhou 256699,China;Department of Oral and Maxillofacial Surgery,Taian Central Hospital,Taian 271099,China)
出处
《中国医师杂志》
CAS
2022年第12期1909-1912,共4页
Journal of Chinese Physician
基金
山东省自然科学基金(ZR2019PH075)。
