临沂市一例Omicron BA.5.2变异株全基因组序列分析

COMPLETE GENOME SEQUENCE ANALYSIS OF OMICRON BA.5.2 VARIANT IN LINYI

目的 探讨临沂市一起Omicron BA.5.2的全基因组序列,并根据结果进行溯源。方法 对本疫情患者进行流行病学调查,对采集的Omicron BA.5.2进行核酸检测和全基因组序列测定分析。结果 本次疫情共有12人感染,潜伏期中位数M为2.5 d。测得8份全基因组序列同亚洲其他国家的5份序列聚成一簇,亲缘关系较近。较GISAID上的其他序列,8份序列新增C884T、C7728T、C18647T、G23608T四个核苷酸变异位点。结论 本次疫情由外地返临人员引起,主要通过密接、同时空交集传播,SARS-CoV-2核酸检测以及做好个人防护仍然是阻止疫情扩散的重要手段。

Objective To explore the whole genome sequence of Omicron BA. 5.2 in Linyi City and trace the source according to the results. Methods Epidemiological investigation was carried out on the epidemic patients, and nucleic acid detection and whole genome sequencing were performed on Omicron BA. 5.2 collected. Results A total of 12 people were infected in this epidemic, and the median incubation period M was 2.5 days. Eight whole genome sequences were clustered together with five sequences from other Asian countries, showing close genetic relationship. Compared with other sequences on GISAID, the 8 sequences added four nucleotide mutation sites: C884T, C7728T, C18647T, G23608T. Conclusion The epidemic situation was caused by the returning personnel from other places, and it was mainly transmitted through close contact and intersection of time and space. The detection of SARS CoV-2 nucleic acid and personal protection are still important means to prevent the spread of the epidemic situation.