摘要
变应性鼻炎是一种由花粉、尘螨、真菌孢子、动物皮屑等过敏原诱导的Th2炎症性疾病,发病率达32%,花粉穿透鼻黏膜屏障的机制与通路尚未完全阐明。气传花粉中蛋白水解酶是风传受精过程关键蛋白,同时参与释放花粉颗粒中的前列腺素E2(PGE2)、白三烯B4(LTB4)等炎症介质,尘螨、霉菌中蛋白水解酶可结合蛋白酶激活受体2(PAR-2)破坏细胞间紧密连接,破坏黏膜上皮屏障。真菌中的蛋白水解酶通过激活Ras/Raf1/ERK信号通路介导的Th2炎症反应。综述了花粉、尘螨、真菌中蛋白水解酶介导变应性鼻炎炎症反应的研究进展。
Allergic rhinitis is a Th2 inflammatory disease caused by pollen,dust mites,fungal spores,animal dandruff and other allergens,with an incidence of 32%of the general population.The mechanism and pathway of pollen penetrating the nasal mucosal barrier have not been fully clarified.Proteolytic enzyme in airborne pollen is a key protein in the process of wind-borne fertilization,and is involved in the release of inflammatory mediators such as prostaglandin E2(PGE2)and leukotriene B4(LTB4)in pollen grains.Proteolytic enzymes in dust mites and molds can binding to protease-activated receptor 2(PAR-2),destroy the tight connection between cells and destroy the mucosal epithelial barrier.Th2 inflammation is mediated by proteolytic enzymes in fungi by activating Ras/Raf1/ERK signaling pathway.This article reviews the research progress on how proteolytic enzymes in pollen,dust mites and fungi mediate the inflammatory response of allergic rhinitis.
作者
李智敏
王姚俊
池佼妮
王涛
李强
LI Zhi-min;WANG Yao-jun;CHI Jiao-ni;WANG Tao;LI Qiang(Graduate School,Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Dermatology,Air Force Medical Center,PLA,Beijing 100142,China;The Fifth School of Clinical Medicine,Anhui Medical University,Hefei,Anhui 230032,China)
出处
《河北北方学院学报(自然科学版)》
2023年第2期57-60,F0003,共5页
Journal of Hebei North University:Natural Science Edition
关键词
变应性鼻炎
蛋白水解酶
花粉
尘螨
allergic rhinitis
proteolytic enzyme
pollen
house dust mite