早期肝癌患者应用超声引导下微波治疗术和外科手术治疗的效果观察

Effect observation of ultrasound-guided microwave therapy and surgery on patients with early hepatocellular carcinoma

目的探讨早期肝癌患者应用超声引导下微波治疗术和外科手术的临床效果。方法选择56例早期肝癌患者作为研究对象,根据治疗方式不同分为对照组(26例)与观察组(30例)。对照组应用外科手术治疗,观察组应用超声引导下微波治疗术治疗。对比两组患者癌灶清除及术后复发情况,治疗前后生活质量量表(QOL)评分。结果观察组患者癌灶清除率及术后6个月、1年复发率分别为96.7%、13.3%、26.7%,与对照组的100.0%、11.5%、26.9%比较差异均无统计学意义(P>0.05)。治疗前,两组患者的躯体功能、心理功能、社会功能、物质生活评分和总分对比差异无统计学意义(P>0.05);治疗后,两组患者的躯体功能、心理功能、社会功能、物质生活评分和总分均高于本组治疗前,且观察组患者的躯体功能评分(87.84±5.37)分、心理功能评分(85.75±4.37)分、社会功能评分(88.48±4.74)分、物质生活评分(74.85±3.85)分和总分(85.36±3.58)分均明显高于对照组的(77.04±5.54)、(77.39±4.73)、(77.37±4.37)、(66.39±3.95)、(75.70±3.43)分,差异具有统计学意义(P<0.05)。结论早期肝癌患者应用超声引导下微波治疗术与外科手术治疗的效果相当,可有效提升患者生活质量,改善患者心理状态,建议临床应用。

Objective To discuss the clinical effect of ultrasound-guided microwave therapy and surgery on patients with early hepatocellular carcinoma. Methods A total of 56 patients with early hepatocellular carcinoma were divided into control group(26 cases) and observation group(30 cases) according to different treatment methods. The control group was treated with surgery, and the observation group was treated with ultrasound-guided microwave therapy. The clearance of cancer foci, postoperative recurrence, quality of life scale(QOL) score before and after treatment were compared between the two groups. Results The clearance rates of cancer foci and the recurrence rate at 6 months and 1 year after surgery in the observation group were 96.7%, 13.3% and 26.7%, which had no statistically significant difference compared with 100.0%, 11.5% and 26.9% in the control group(P>0.05). Before treatment, there were no statistically significant differences in the scores of physical function, psychological function, social function, material life and total score between the two groups(P>0.05). After treatment, the scores of physical function, psychological function, social function, material life and total score of the two groups were higher than those of this group before treatment;the physical function score(87.84±5.37) points, psychological function score(85.75±4.37) points, social function score(88.48±4.74) points, material life score(74.85±3.85) points and total score(85.36±3.58) points in the observation group were significantly higher than(77.04±5.54),(77.39±4.73),(77.37±4.37),(66.39±3.95) and(75.70±3.43) points in the control group;the differences were statistically significant(P<0.05). Conclusion Ultrasoundguided microwave therapy for patients with early hepatocellular carcinoma has no difference in therapeutic effect from surgical treatment, which can effectively improve the quality of life of patients and improve the psychological state of patients. Therefore, it is recommended for clinical application.