米拉贝隆治疗TURP术后膀胱痉挛的临床疗效研究

Study on clinical efficacy of miraberone in the treatment of bladder spasm after TURP

目的 研究米拉贝隆治疗经尿道前列腺切除术(TURP)术后膀胱痉挛的临床效果。方法 60例行TURP术后出现膀胱痉挛患者,随机分为观察组和对照组,每组30例。所有患者均进行腹部肌肉锻炼,观察组在上述治疗方案的基础上使用米拉贝隆缓释片治疗。比较两组患者临床疗效、置管期排尿情况(膀胱痉挛次数、膀胱痉挛时间、排尿次数)、自主排尿期排尿情况(尿量、急迫性尿失禁次数、尿急次数)。结果 观察组治疗总有效率93.33%高于对照组的73.33%,差异具有统计学意义(P<0.05)。观察组患者膀胱痉挛次数(6.4±1.2)次/周、排尿次数(7.1±1.2)次/d少于对照组的(14.1±3.6)次/周、(9.5±2.6)次/d,膀胱痉挛时间(9.9±3.1)min/次短于对照组的(22.1±7.2)min/次,差异均具有统计学意义(P<0.05)。观察组患者自主排尿期的尿量(241.2±26.2)ml/次大于对照组的(172.5±18.6)ml/次,急迫性尿失禁次数(0.6±0.4)次/d、尿急次数(1.4±0.7)次/d均少于对照组的(1.2±0.6)、(2.9±1.2)次/d,差异具有统计学意义(P<0.05)。结论 米拉贝隆治疗TURP术后膀胱痉挛的效果显著,可改善患者的不适症状,促进患者恢复,值得广泛应用于临床。

Objective To study the clinical effect of miraberone in the treatment of bladder spasm after transurethral resection of prostate(TURP). Methods A total of 60 patients with bladder spasm after TURP were randomly divided into observation group and control group, with 30 patients in each group. All patients were treated with abdominal muscle exercises, and the observation group was also treated with mirabegron sustainedrelease tablets. Both groups were compared in terms of clinical efficacy, urination during catheterization(frequency of bladder spasms, duration of bladder spasms, and frequency of urination), and urination during autonomous urination(urine volume, frequency of urgent incontinence, and frequency of urgent urination). Results The total effective rate of the observation group was 93.33%, which was higher than 73.33% of the control group, and the difference was statistically significant(P<0.05). The frequency of bladder spasm and urination in the observation group were(6.4±1.2) times/week and(7.1±1.2) times/d, which were lower than(14.1±3.6) times/week and(9.5±2.6) times/d in the control group;the duration of bladder spasms in the observation group was(9.9±3.1) min/time, which was shorter than(22.1±7.2) min/time in the control group;the differences were statistically significant(P<0.05). The urine volume of autonomous urination of the observation group was(241.2±26.2) ml/time, which was higher than(172.5±18.6) ml/time of the control group;the frequency of urgent incontinence(0.6±0.4) times/d and frequency of urgent urination(1.4±0.7) times/d of the observation group were less than(1.2±0.6) and(2.9±1.2) times/d of the control group;the differences were statistically significant(P<0.05). Conclusion Miraberone is effective in the treatment of bladder spasm after TURP, and can improve the uncomfortable symptoms and promote the recovery of the patients, which is worth to be widely used in clinic.