血管紧张素转换酶2-血管紧张素(1-7)-Mas受体轴抗炎机制研究进展

Research Progress on Anti-inflammatory Effects of Angiotensin Converting Enzyme 2-angiotensin(1-7)-Mas Receptor Axis

肾素-血管紧张素系统(RAS)与炎症反应关系密切。血管紧张素Ⅱ(AngⅡ)是RAS的主要参与者,可激活与组织损伤、炎症相关的信号通路,而血管紧张素转换酶2(ACE2)-血管紧张素(Ang)(1-7)-Mas受体轴可发挥与AngⅡ相反的作用,抑制炎症反应。本文拟对ACE2-Ang(1-7)-Mas受体轴的基本特性及其在心血管疾病、肾病、肺损伤、神经性疾病中的抗炎机制的研究进展作一综述。

The renin angiotensin system(RAS)is closely related to inflammation.AngiotensinⅡ(AngⅡ)is a major participant in RAS which activates signaling pathways related to tissue damage and inflammation.Angiotensin converting enzyme 2(ACE2)-angiotensin(Ang)(1-7)-Mas receptor axis plays an opposite role to AngⅡ,that is inflammation-inhibiting.This article reviews the primary properties of ACE2-Ang(1-7)-Mas axis and its anti-inflammatory mechanisms in cardiovascular disease,kidney disease,lung injury and neurological disease.