抑郁症患者生活质量及其相关因素分析

Analysis on quality of life and related factors in patients with depression

目的分析抑郁症患者生活质量及其相关因素,为制定提高患者生活质量的对策提供参考。方法于2018年11月19日-2019年9月7日在湛江中心人民医院、广东医科大学附属医院、广东三九脑科医院选取符合《国际疾病分类(第10版)》(ICD-10)抑郁症诊断标准的住院患者117例。通过查阅病历,收集患者血常规、尿常规、血生化检查、血气分析等临床客观指标,采用抑郁症患者生活质量测定量表QLICD-DE(V2.0)评定患者生活质量。采用简单相关分析探讨QLICD-DE(V2.0)评分与各临床客观指标的相关性,并使用多重线性回归分析进一步筛选与抑郁症患者生活质量相关的因素。结果简单相关分析显示,抑郁症患者QLICD-DE(V2.0)总评分与血清总蛋白和血小板分布宽度均呈正相关(r=0.198、0.281,P<0.05或0.01),与红细胞压积呈负相关(r=-0.300,P<0.01)。多重线性回归分析结果显示,血清白/球蛋白比值和治疗依从性(B=-19.836、-3.711,P<0.05或0.01)是躯体功能的影响因素;血小板分布宽度(B=2.706,P<0.01)是心理功能的影响因素;胆红素(B=-6.375,P<0.05)是社会功能的影响因素;血小板分布宽度(B=2.101,P<0.05)是特异模块的影响因素;血清白/球蛋白比值和血小板分布宽度(B=-10.653、2.114,P<0.05或0.01)是QLICD-DE(V2.0)总评分的影响因素。结论治疗依从性以及临床客观指标中的血小板分布宽度、胆红素、血清白/球蛋白比值可能是抑郁症患者生活质量的影响因素。

Objective To analyze the quality of life and related factors in patients with depression,and to provide evidence for formulating the corresponding measures to improve the patients′quality of life.Methods A total of 117 inpatients who met the International Classification of Diseases,tenth edition(ICD-10)for depression were selected in Central People′s Hospital of Zhanjiang,Affiliated Hospital of Guangdong Medical University and Guangdong 999 Brain Hospital from November 19,2018 to September 7,2019.The values of patients′clinical objective indicators consisted of routine blood test,routine urine examination,blood biochemical tests and blood gas analysis were collected by reviewing their medical records,and all subjects were assessed using Quality of Life Instruments for Chronic Diseases-Depression V2.0[QLICD-DE(V2.0)].Simple correlation analysis was used to explore the correlation between the QLICD-DE(V2.0)scores and various clinical objective indicators,and multiple linear regression was adopted to further screen factors affecting quality of life of patients with depression.Results Simple correlation analysis suggested that QLICD-DE(V2.0)total score was positively correlated with total protein and platelet distribution width in patients with depression(r=0.198,0.281,P<0.05 or 0.01),and negatively correlated with hematocrit(r=-0.300,P<0.01).Multiple linear regression analysis showed that albumin-to-globulin ratio and treatment compliance(B=-19.836,-3.711,P<0.05 or 0.01)were influential factors for physical function.Platelet distribution width(B=2.706,P<0.01)was an influential factor for psychological function.Bilirubin(B=-6.375,P<0.05)was an influential factor for social function.Platelet distribution width(B=2.101,P<0.05)was an influencing factor for specific module.The albumin-to-globulin ratio and platelet distribution width(B=-10.653,2.114,P<0.05 or 0.01)were influencing factors for total score of QLICD-DE(V2.0).Conclusion Treatment compliance and clinical objective indicators platelet distribution width,bilirubin and albumin-to-globulin ratio may be the influencing factors of quality of life in patients with depression.