肾周脂肪在糖尿病肾病中的作用及机制研究进展

Research progress on the role and mechanism of perirenal adipose tissue in diabetic nephropathy

糖尿病肾病(DN)是糖尿病预后不良的严重微血管并发症之一,在老年人群中发病率逐年增高,严重影响其生存质量。肾周脂肪与肾脏相邻,在脂质代谢、脂肪因子及促炎细胞因子分泌等方面非常活跃。肾周脂肪是DN的独立危险因素。在DN中肾周脂肪可通过局部压迫、脂肪因子分泌与氧化应激、肾素—血管紧张素—醛固酮系统的激活等多种途径介导肾功能损伤。本文旨在总结近期肾周脂肪在DN发病过程中的作用及可能机制,以探讨肾周脂肪在DN中的应用前景。

Diabetic nephropathy is one of the serious microvascular complications with poor prognosis in diabetes,and the incidence of diabetic nephropathy in the elderly population is increasing year by year,seriously affecting their quality of life.Perirenal adipose tissue is adjacent to the kidneys and is very active in lipid metabolism,adipokine and proinflammatory cytokine secretion.Perirenal adipose tissue is an independent risk factor for diabetic nephropathy.In diabetic nephropathy,perirenal adipose tissue can mediate renal impairment through local compression,adipokine secretion and oxidative stress,and activation of renin-angiotensin-aldosterone system.The purpose of this review is to summarize the recent role and possible mechanisms of perirenal adipose tissue in the pathogenesis of diabetic nephropathy,in order to explore the application prospects of perirenal adipose tissue in diabetic nephropathy.