强直性脊柱炎相关非编码RNA研究进展

New advances in non-coding RNA related to ankylosing spondylitis

强直性脊柱炎(AS)是一种以骶髂关节、肌腱以及肌腱附着点炎症为主要症状的自身免疫疾病,多表现为关节强直及脊柱畸形,其发病机制尚未明确。非编码RNA(ncRNA)在人体中广泛参与病理生理的调控过程。目前研究结果显示多种ncRNA与AS发病密切相关,可作为AS的诊断生物标志物或基因治疗靶点。本文就近几年中与AS相关的ncRNA作一综述,以期为AS的诊断和治疗提供新的思路及靶点。

Ankylosing spondylitis(AS)is an autoimmune disease with inflammation of sacroiliac joints,tendons and tendon attachments as the main symptoms,mostly manifested as joint stiffness and spinal deformity,and its pathogenesis is not clear yet.Non-coding RNA(ncRNA)is widely involved in the regulation process of pathophysiology in human body.Current studies have found that a variety of ncRNA are closely related to the pathogenesis of AS and can be used as diagnostic biomarkers or gene therapy targets for AS.In this review,ncRNA related to AS in recent years are reviewed in order to provide new ideas and targets for diagnosis and treatment of AS.