继发性甲状旁腺功能亢进症的甲状旁腺激素基因转录后调控机制研究进展

Research progress on post-transcriptional mechanisms of parathyroid hormone gene expression regulation in secondary hyperparathyroidism

继发性甲状旁腺功能亢进症(secondary hyperparathyroidism,SHPT)是以甲状旁腺激素(parathyroid hormone,PTH)分泌增加为特征的慢性肾脏病患者最常见的严重并发症之一。多项研究证实,PTH mRNA相关结合蛋白和miRNAs参与靶基因PTH转录后调控机制,调节PTH mRNA的稳定性和水平,对SHPT中高PTH表达起重要作用。转录后调控机制可能作为指导SHPT诊治的潜在临床应用价值亟待进一步探索。本文将就SHPT的PTH基因转录后调控机制研究进展展开综述。

Secondary hyperparathyroidism(SHPT)is one of the most common severe complications in chronic kidney disease patients and characterized by elevated parathyroid hormone(PTH). Studies have confirmed that PTH mRNA-related binding proteins and miRNAs regulate the stability and expression of PTH mRNA,thereby mediating its post-transcriptional regulatory mechanism and playing an essential role in the high level of PTH in SHPT. The potential clinical application value of post-transcriptional regulation in the diagnosis and treatment of SHPT remains further explored. This paper reviews the current progression in the post-transcriptional regulation mechanism of the PTH gene in SHPT.