癌症患者恶病质脂肪酸代谢研究进展

Advances in fatty acid metabolism in cancer patients with cachexia

癌症预计成为人类健康的头号杀手。近年来关于癌症营养代谢的研究迅速增多,包括葡萄糖、氨基酸和脂肪酸等营养物质对肿瘤细胞增殖和扩散的影响。恶病质是影响癌症患者预后的关键因素,约80%的癌症患者罹患恶病质导致癌症治疗失败。针对恶病质的药物治疗和饮食治疗目前还缺乏临床研究。本综述主要通过脂肪酸对肿瘤细胞增殖和转移的影响以及恶病质脂肪酸相关药物及饮食治疗对胃癌恶病质脂肪酸代谢研究进展进行综述。

Cancer is expected to become the number one killer of human health.,In recent years,there has been a surge in research on the nutritional metabolism of cancer,including the effects of nutrients such as glucose,amino acids,and fatty acids on the proliferation and spread of cancer.Cachexia is a key factor affecting the prognosis of cancer.About 80% of cancer patients suffer from cachexia,which leads to the failure of cancer treatment.At present,there are still many clinical studies on drug therapy and dietary therapy for cachexia.This review mainly reviews the research progress of cachexia fatty acid metabolism in gastric cancer through the effects of fatty acids on cancer cell proliferation and metastasis,cachexia fatty acid-related drugs,and dietary therapy.