视神经脊髓炎相关视神经炎诊治进展

Progress in the diagnosis and treatment of neuromyelitis optica spectrum disorder optic neuritis

视神经脊髓炎相关性视神经炎(neuromyelitis optica spectrum disorder optic neuritis,NMO-ON)是一种常见的视神经炎(optic neuritis,ON)类型。女性非白种人占优势,损伤严重,双侧受累较多,视力预后差。我国有很大部分特发性ON最终诊断为NMO-ON。在相关实验室、光学相干断层扫描(optical coherence tomography,OCT)、磁共振(magnetic resonance imaging,MRI)等技术支持下,目前对NMO-ON的认识有了很大的进步,治疗方式除了皮质类固醇外还有免疫球蛋白、血浆置换及免疫抑制剂等。但提高NMO-ON的诊疗水平还有很长的路,更好地认识NMO-ON有助于更快速的诊断、更规范的治疗、更良好的预后。我们可以联合神经科开展多中心大样本量前瞻性的临床对照研究。

Neuromyelitis optica spectrum disorder-optic neuritis(NMO-ON) is a common type of optic neuritis(ON).This affliction is predominant in female non-Caucasians,with severe injury,more bilateral involvement,and poor visual prognosis.In China,a large proportion of idiopathic ON is ultimately diagnosed as NMO-ON.Our understanding of NMO-ON has made great progress under the technical support,such as the relevant laboratory;optical coherence tomography(OCT),magnetic resonance imaging(MRI).In addition to corticosteroids,immunoglobulin,plasmapheresis and immunosuppressive agents are also available for treatment.However,there is still a long way to improve the diagnosis and treatment level of NMO-ON.A better understanding of NMO-ON contributes to faster diagnosis,more standardized treatment,and better prognosis.We should cooperate with the neurology department to conduct a multi-center,large sample size prospective clinical control study.